ORCID Profile
0000-0003-0677-734X
Current Organisations
Australian National University
,
Deakin University
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Publisher: American Astronomical Society
Date: 03-04-2012
Publisher: EDP Sciences
Date: 20-09-2011
Publisher: American Astronomical Society
Date: 28-10-2011
Publisher: EDP Sciences
Date: 2012
Publisher: ACM Press
Date: 2015
Publisher: Springer US
Date: 2006
Publisher: American Astronomical Society
Date: 17-09-2012
Publisher: Springer International Publishing
Date: 2021
Publisher: Elsevier BV
Date: 06-2003
Publisher: Elsevier BV
Date: 12-2017
DOI: 10.1016/J.PBIOMOLBIO.2017.08.014
Abstract: It is difficult to model emergence in biological systems using reductionist paradigms. A requirement for computational modeling is that in idual entities can be recorded parametrically and related logically, but their transformation into whole systems cannot be captured this way. The problem stems from an inability to formally represent the implicit influences that inform emergent organization, such as context, shifts in causal agency or scale, and self-reference. This lack h ers biological systems modeling and its computational counterpart, indicating a need for new fundamental abstraction frameworks that support system-level characteristics. We develop an approach that formally captures these characteristics, focusing on the way they come together to enable transformation at the 'peak' of the emergent process. An ex le from virology is presented, in which two seemingly antagonistic systems - the herpes cold sore virus and its host - are capable of altering their basic biological objectives to achieve a new equilibrium. The usual barriers to modeling this process are overcome by incorporating mechanisms from practices centered on its emergent peak: design and katachi. In the Japanese science of form, katachi refers to the emergence of intrinsic structure from real situations, where an optimal balance between implicit influences is achieved. Design indicates how such optimization is guided by principles of flow. These practices leverage qualities of situated abstraction, which we understand through the intuitive method of physicist Kôdi Husimi. Early results indicate that this approach can capture the functional transformations of biological emergence, whilst being reasonably computable. Due to its geometric foundations and narrative-based extension to logic, the method will also generate speculative predictions. This research forms the foundations of a new biomedical modeling platform, which is discussed.
Publisher: Springer US
Date: 2004
Publisher: Elsevier BV
Date: 06-2016
Publisher: Springer-Verlag
Date: 2005
Publisher: American Astronomical Society
Date: 25-07-2012
Publisher: Elsevier BV
Date: 09-2013
DOI: 10.1016/J.PBIOMOLBIO.2013.03.015
Abstract: Structural modeling of complex biological systems relies on formalisms inherited from physics. These formalisms scale poorly when dealing with interactions with many variables and agents working in systems that cohere at multiple layers. We propose a two sorted logic that supplements existing formalisms to mitigate these problems. The purpose of this second logic is to track how multiple contexts relate to each other, as well as to the dependent structures they inform: a situating of situations. In this way, we aim to capture the multi-layered and multi-system dynamics that have been elusive in modeling emergent systems. An apoptosis ex le is explored in the context of mental concepts.
Publisher: IGI Global
Date: 2014
DOI: 10.4018/978-1-4666-5142-5.CH013
Abstract: Studies show that enterprises are severely constrained by their management structures, and that those constraints become more vexing as information technologies are adopted. This is more true as “interoperability engineering” advances the enterprise is capable of doing simple, ordinary things better, but the form of the enterprise becomes less adaptive, less agile as external firms are integrated in using lowest common denominator standards. The net result is that we are worse off now because of the constraints of integration decisions. A radical advance is required, one based on breakthroughs in the underlying science used by enterprise engineers. This chapter indicates one advanced form of enterprise that current research could make possible and uses it to illustrate desired enterprise engineering tools. It then suggests an agenda for fundamental research to support those goals.
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Elsevier
Date: 2020
Publisher: American Astronomical Society
Date: 06-04-2011
Publisher: American Astronomical Society
Date: 14-04-2011
Publisher: American Astronomical Society
Date: 15-09-2011
Publisher: Elsevier
Date: 2020
Publisher: Oxford University Press (OUP)
Date: 15-06-2011
Publisher: Springer US
Date: 2001
Publisher: American Association for the Advancement of Science (AAAS)
Date: 08-04-2011
Abstract: Measurements of 500 Sun-like stars show that their properties differ from those predicted by stellar population models.
Publisher: Springer-Verlag
Date: 2005
Publisher: Springer Berlin Heidelberg
Date: 1997
Publisher: Elsevier BV
Date: 2020
Publisher: American Astronomical Society
Date: 10-05-2011
Publisher: Elsevier BV
Date: 12-2015
DOI: 10.1016/J.PBIOMOLBIO.2015.07.006
Abstract: We approach a well-known problem: how to relate component physical processes in biological systems to governing imperatives in multiple system levels. The intent is to further practical tools that can be used in the clinical context. An ex le proposes a formal type system that would support this kind of reasoning, including in machines. Our ex le is based on a model of the connection between a quality of mind associated with creativity and neuropsychiatric dynamics: constructing narrative as a form of conscious introspection, which allows the manipulation of one's own driving imperatives. In this context, general creativity is indicated by an ability to manage multiple heterogeneous worldviews simultaneously in a developing narrative. 'Narrative' in this context is framed as the organizing concept behind rational linearization that can be applied to metaphysics as well as modeling perceptive dynamics. Introspection is framed as the phenomenological 'tip' that allows a perceiver to be within experience or outside it, reflecting on and modifying it. What distinguishes the approach is the rooting in well founded but disparate disciplines: phenomenology, ontic virtuality, two-sorted geometric logics, functional reactive programming, multi-level ontologies and narrative cognition. This paper advances the work by proposing a type strategy within a two-sorted reasoning system that supports cross-ontology structure. The paper describes influences on this approach, and presents an ex le that involves phenotype classes and monitored creativity enhanced by both soft methods and transcranial direct-current stimulation. The proposed solution integrates pragmatic phenomenology, situation theory, narratology and functional programming in one framework.
Publisher: Springer US
Date: 2003
Location: United States of America
No related grants have been discovered for Ted Goranson.