ORCID Profile
0000-0002-7023-0800
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Publisher: The Royal Society
Date: 20-09-2023
Publisher: Cold Spring Harbor Laboratory
Date: 19-05-2020
DOI: 10.1101/2020.05.19.103846
Abstract: Since spilling over into humans, SARS-CoV-2 has rapidly spread across the globe, accumulating significant genetic ersity. The structure of this genetic ersity, and whether it reveals epidemiological insights, are fundamental questions for understanding the evolutionary trajectory of this virus. Here we use a recently developed phylodynamic approach to uncover phylogenetic structures underlying the SARS-CoV-2 pandemic. We find support for three SARS-CoV-2 lineages co-circulating, each with significantly different demographic dynamics concordant with known epidemiological factors. For ex le, Lineage C emerged in Europe with a high growth rate in late February, just prior to the exponential increase in cases in several European countries. Mutations that characterize Lineage C in particular are non-synonymous and occur in functionally important gene regions responsible for viral replication and cell entry. Even though Lineages A and B had distinct demographic patterns, they were much more difficult to distinguish. Continuous application of phylogenetic approaches to track the evolutionary epidemiology of SARS-CoV-2 lineages will be increasingly important to validate the efficacy of control efforts and monitor significant evolutionary events in the future.
Publisher: SCIK Publishing Corporation
Date: 2020
DOI: 10.28919/CMBN/4535
Location: Ghana
Start Date: 2020
End Date: 2024
Funder: University of Tasmania
View Funded ActivityStart Date: 2015
End Date: 2016
Funder: African Institute for Mathematical Sciences
View Funded Activity