ORCID Profile
0000-0002-2967-3634
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: American Chemical Society (ACS)
Date: 13-08-2020
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.XPHS.2019.06.020
Abstract: The theoretical amorphous solubility enhancement ratio (R
Publisher: American Chemical Society (ACS)
Date: 03-04-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2AN01856J
Abstract: A novel platform for direct transfer, separation, and pre-concentration of swabbed s les without elution into a solvent or a medium.
Publisher: Springer Science and Business Media LLC
Date: 11-2021
Publisher: Elsevier BV
Date: 03-2018
DOI: 10.1016/J.XPHS.2017.11.006
Abstract: The present work highlights the use of miniaturized approaches to screen and prioritize development of solid dispersions that provide stabilization of the amorphous drug against crystallization and enhanced dissolution over the crystalline form. The approaches evaluated include solvent casting and solvent displacement-based techniques. Four compounds were evaluated with both these screening approaches. A dual-pH dilution method using fasted state simulated gastric fluid and fasted state simulated intestinal fluid as media was used to evaluate solubility enhancement ratio in each well of the screen. The concentration at 15 mins after dilution with fasted state simulated intestinal fluid and super-saturation ratio at the end of the dissolution study is used as 2 descriptors of solubility enhancement. The empirical screening approaches were supplemented with theoretical calculations of solubility enhancement to gauge the best-performing amorphous solid dispersion (ASD). Physical stability of the amorphous systems was also evaluated, where applicable. Lead ASD compositions from the screens were scaled up to verify the predictions. To our knowledge, this is the first report where the 2 most common screening approaches for the development of ASDs are compared head to head. These approaches are rapid, material sparing, and can be adapted to accommodate screening of multiple variables such as polymer type, drug load, and ternary systems simultaneously. The strengths, limitations, and most suitable applications for each of the 2 methods are also discussed.
Publisher: American Chemical Society (ACS)
Date: 14-09-2017
DOI: 10.1021/ACS.JNATPROD.7B00425
Abstract: Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced by the monoamine storage blocker tetrabenazine. Tetrabenazine shifted effort-related choice in rats, decreasing high-effort lever pressing but increasing chow intake. The effects of tetrabenazine were reversed by oral ingestion of curcumin (80.0-160.0 mg/kg) and infusions of curcumin into the cerebral ventricles (2.0-8.0 μg). Curcumin attenuates the effort-related effects of tetrabenazine in this model via actions on the brain, suggesting that curcumin may be useful for treating human motivational symptoms.
Publisher: Elsevier BV
Date: 06-2020
No related grants have been discovered for Arushi Manchanda.