ORCID Profile
0000-0002-6311-860X
Current Organisation
Childrens' Health Queensland
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Publisher: Wiley
Date: 02-03-2020
DOI: 10.1002/JPPR.1598
Publisher: Wiley
Date: 06-2021
DOI: 10.1002/JPPR.1746
Abstract: Benzylpenicillin and flucloxacillin are commonly used in outpatient parenteral antibiotic therapy (OPAT). Published evidence supporting the stability of buffered infusions, in a variety of devices and concentrations, using an Australian commercially available buffer, to suit a paediatric setting is desirable. The aim of this study was to determine if multiple concentrations of buffered benzylpenicillin and flucloxacillin, prepared in suitable infusion devices, exposed to a variety of temperatures, maintained stability. Benzylpenicillin (15 and 60 mg/mL) and flucloxacillin (5 and 60 mg/mL) infusions in LV Elastomeric Infusor devices and sodium chloride 0.9% Viaflex bags were prepared as buffered and unbuffered solutions. Buffering was achieved by reconstituting antibiotic vials with sodium citrate 4%. Infusions were stored at 2–8°C for 6 days then 37°C for 24 h. S les were taken on day 0, 1, 3, 6 and 7. The concentration, pH, colour and appearance were assessed at each time point. The concentration of all day 7 buffered benzylpenicillin s les was maintained between 97.70–100.36% and flucloxacillin 98.7–100.66% of the initial concentration. Unbuffered solutions did not retain antibiotic potency over the same study period. There was minimal pH change in buffered benzylpenicillin s les from 6.66 to 5.5 and flucloxacillin 6.58 to 6.19. There was no visual change in colour or appearance. Buffered benzylpenicillin 15 and 60 mg/mL and flucloxacillin 5 and 60 mg/mL in LV Elastomeric Infusors and sodium chloride 0.9% Viaflex bags, appear chemically stable for 6 days refrigerated, and for a subsequent 24 h at 37°C.
Publisher: Wiley
Date: 04-2020
DOI: 10.1002/JPPR.1614
Publisher: Wiley
Date: 04-03-2018
DOI: 10.1002/JPPR.1347
Publisher: Wiley
Date: 21-08-2007
DOI: 10.1002/PBC.21342
No related grants have been discovered for Evonne Smith.