Helene Aflenzer

Supplementary Table 2 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779466.V1

Abstract: Multivariable adjusted hazard ratios for all-cause and cause-specific hospitalisations, major cancer diagnostic group.

High‐risk B‐cell acute lymphoblastic leukaemia presenting with hypereosinophilia and acquiring a novel PAX5 fusion on relapse

Publisher: Wiley

Date: 30-07-2020

DOI: 10.1111/BJH.17002

Effect of dissolved iron (II) and temperature on growth of the Southern Ocean phytoplankton species Fragilariopsis cylindrus and Phaeocystis antarctica

Publisher: Springer Science and Business Media LLC

Date: 24-09-2023

DOI: 10.1007/S00300-023-03191-Z

Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 06-07-2023

DOI: 10.1158/1055-9965.EPI-22-1313

Abstract: The long-term effects of childhood cancer are unclear in the Australian context. We examined hospitalization trends for physical diseases and estimated the associated inpatient care costs in all 5-year childhood cancer survivors (CCS) diagnosed in Western Australia (WA) from 1982 to 2014. Hospitalization records for 2,938 CCS and 24,792 comparisons were extracted from 1987 to 2019 (median follow-up = 12 years, min = 1, max = 32). The adjusted hazard ratio (aHR) of hospitalization with 95% confidence intervals (CI) was estimated using the Andersen–Gill model for recurrent events. The cumulative burden of hospitalizations over time was assessed using the mean cumulative count method. The adjusted mean cost of hospitalization was estimated using the generalized linear models. We identified a higher risk of hospitalization for all-cause (aHR, 2.0 95% CI, 1.8–2.2) physical disease in CCS than comparisons, with the highest risk for subsequent malignant neoplasms (aHR, 15.0 95% CI, 11.3–19.8) and blood diseases (aHR, 6.9 95% CI, 2.6–18.2). Characteristics associated with higher hospitalization rates included female gender, diagnosis with bone tumors, cancer diagnosis age between 5 and 9 years, multiple childhood cancer diagnoses, multiple comorbidities, higher deprivation, increased remoteness, and Indigenous status. The difference in the mean total hospitalization costs for any disease was significantly higher in survivors than comparisons (publicly funded $11,483 United States Dollar, P & 0.05). The CCS population faces a significantly higher risk of physical morbidity and higher cost of hospital-based care than the comparisons. Our study highlights the need for long-term follow-up healthcare services to prevent disease progression and mitigate the burden of physical morbidity on CCS and hospital services.

Supplementary Figure 2 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779472.V1

Abstract: The mean cumulative count of hospitalisations for any physical-health disease by attained age, in childhood cancer survivors and their matched comparisons.

Supplementary Table 1 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779469

Abstract: Major diagnostic groups of physical-health diseases based on the International Classification of Diseases (ICD), 9th (Clinical modification) and 10th (Australian Modification) revisions.

Supplementary Table 2 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779466

Abstract: Multivariable adjusted hazard ratios for all-cause and cause-specific hospitalisations, major cancer diagnostic group.

Supplementary Figure 1 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779475

Abstract: The mean cumulative count of hospitalisations for any physical-health disease by time since index cancer diagnosis, in childhood cancer survivors.

Supplementary Table 3 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779463

Abstract: Adjusted annual mean costs of privately funded hospitalisations per in idual, by all-cause and cause-specific physical diseases.

Supplementary Figure 2 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779472

Abstract: The mean cumulative count of hospitalisations for any physical-health disease by attained age, in childhood cancer survivors and their matched comparisons.

Supplementary Table 1 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779469.V1

Abstract: Major diagnostic groups of physical-health diseases based on the International Classification of Diseases (ICD), 9th (Clinical modification) and 10th (Australian Modification) revisions.

Supplementary Table 3 from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 26-07-2023

DOI: 10.1158/1055-9965.23779463.V1

Abstract: Adjusted annual mean costs of privately funded hospitalisations per in idual, by all-cause and cause-specific physical diseases.

Data from Hospitalizations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: A Longitudinal Matched Cohort Study

Publisher: American Association for Cancer Research (AACR)

Date: 09-2023

DOI: 10.1158/1055-9965.C.6760427

Abstract: AbstractBackground: The long-term effects of childhood cancer are unclear in the Australian context. We examined hospitalization trends for physical diseases and estimated the associated inpatient care costs in all 5-year childhood cancer survivors (CCS) diagnosed in Western Australia (WA) from 1982 to 2014. Methods: Hospitalization records for 2,938 CCS and 24,792 comparisons were extracted from 1987 to 2019 (median follow-up = 12 years, min = 1, max = 32). The adjusted hazard ratio (aHR) of hospitalization with 95% confidence intervals (CI) was estimated using the Andersen–Gill model for recurrent events. The cumulative burden of hospitalizations over time was assessed using the mean cumulative count method. The adjusted mean cost of hospitalization was estimated using the generalized linear models. Results: We identified a higher risk of hospitalization for all-cause (aHR, 2.0 95% CI, 1.8–2.2) physical disease in CCS than comparisons, with the highest risk for subsequent malignant neoplasms (aHR, 15.0 95% CI, 11.3–19.8) and blood diseases (aHR, 6.9 95% CI, 2.6–18.2). Characteristics associated with higher hospitalization rates included female gender, diagnosis with bone tumors, cancer diagnosis age between 5 and 9 years, multiple childhood cancer diagnoses, multiple comorbidities, higher deprivation, increased remoteness, and Indigenous status. The difference in the mean total hospitalization costs for any disease was significantly higher in survivors than comparisons (publicly funded $11,483 United States Dollar, i P /i 0.05). Conclusions: The CCS population faces a significantly higher risk of physical morbidity and higher cost of hospital-based care than the comparisons. Impact: Our study highlights the need for long-term follow-up healthcare services to prevent disease progression and mitigate the burden of physical morbidity on CCS and hospital services. /

SA Health

Location: Australia

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University Of Adelaide

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Universiteit Gent

Location: Belgium

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University Of Miami

Location: United States of America

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Karl-Franzens-Universität Graz

Location: Austria

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Universitat Salzburg Naturwissenschaftliche Fakultat

Location: Austria

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Université Pierre Et Marie Curie

Location: France

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University Of Tasmania

Location: Australia

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Universität Bremen

Location: Germany

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Linkage Projects - Grant ID: LP0219322

Start Date: 07-2002

End Date: 01-2007

Amount: $67,635.00

Funder: Australian Research Council

Discovery Projects - Grant ID: DP190101782

Start Date: 07-2019

End Date: 12-2023

Amount: $390,000.00

Funder: Australian Research Council