ORCID Profile
0000-0001-5504-0374
Current Organisation
University of British Columbia
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Publisher: American Chemical Society (ACS)
Date: 22-12-2020
Publisher: American Physiological Society
Date: 04-2023
DOI: 10.1152/JAPPLPHYSIOL.00472.2022
Abstract: Exercise and regular physical activity are beneficial for the prevention and management of metabolic diseases such as obesity and type 2 diabetes, whereas exercise cessation, defined as deconditioning from regular exercise or physical activity that has lasted for a period of months to years, can lead to metabolic derangements that drive disease. Adaptations to the insulin-secreting pancreatic β-cells are an important benefit of exercise, whereas less is known about how exercise cessation affects these cells. Our aim is to review the impact that exercise and exercise cessation have on β-cell function, with a focus on the evidence from studies examining glucose-stimulated insulin secretion (GSIS) using gold-standard techniques. Potential mechanisms by which the β-cell adapts to exercise, including exerkine and incretin signaling, autonomic nervous system signaling, and changes in insulin clearance, will also be explored. We will highlight areas for future research.
Publisher: Bioscientifica
Date: 06-2018
DOI: 10.1530/JOE-18-0051
Abstract: The amyloid precursor protein (APP) generates a number of peptides when processed through different cleavage mechanisms, including the amyloid beta peptide that is implicated in the development of Alzheimer’s disease. It is well established that APP via its cleaved peptides regulates aspects of neuronal metabolism. Emerging evidence suggests that amyloidogenic processing of APP can lead to altered systemic metabolism, similar to that observed in metabolic disease states. In the present study, we investigated the effect of APP deficiency on obesity-induced alterations in systemic metabolism. Compared with WT littermates, APP-deficient mice were resistant to diet-induced obesity, which was linked to higher energy expenditure and lipid oxidation throughout the dark phase and was associated with increased spontaneous physical activity. Consistent with this lean phenotype, APP-deficient mice fed a high-fat diet (HFD) had normal insulin tolerance. However, despite normal insulin action, these mice were glucose intolerant, similar to WT mice fed a HFD. This was associated with reduced plasma insulin in the early phase of the glucose tolerance test. Analysis of the pancreas showed that APP was required to maintain normal islet and β-cell mass under high fat feeding conditions. These studies show that, in addition to regulating aspects of neuronal metabolism, APP is an important regulator of whole body energy expenditure and glucose homeostasis under high fat feeding conditions.
Publisher: BMJ
Date: 06-03-2019
DOI: 10.1136/THORAXJNL-2018-212683
Abstract: We examined the interactions between acoustically driven mood modulation and dyspnoea. Following familiarisation, 18 healthy participants attended three experimental sessions on separate days performing two 5 min treadmill tests with a 30 min interval per session while listening to either a positive, negative or neutral set of standardised International Affective Digitised Sounds (IADS). Participants rated intensity and affective domains of dyspnoea during the first exercise test and mood during the second. Mood valence was significantly higher when listening to positive (mean (95% CI): 6.5 (5.9–7.2)) compared with negative sounds (3.6 (2.9–4.4) p .001). Dyspnoea intensity and affect were statistically significantly lower when listening to positive (2.4 (1.8–2.9) and 1.3 (0.7–1.9)) compared with negative IADS (3.2 (2.3–3.7), p=0.013 and 2.3 (1.3–3.3), p=0.009). These findings indicate that acoustically induced mood changes influence exertional dyspnoea.
Publisher: Elsevier BV
Date: 12-2020
No related grants have been discovered for Liam Hall.