ORCID Profile
0000-0002-1793-3881
Current Organisations
BioSurfaces
,
Clarkson University
,
University of Maryland
,
Deakin University
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Functional Materials | Materials Engineering | Manufacturing Processes and Technologies (excl. Textiles) | Composite and Hybrid Materials | Textile Technology | Industrial Chemistry | Organic Chemistry | Organic Green Chemistry | Bioprocessing, Bioproduction and Bioproducts |
ANZSRC Socio-Economic Objective (SEO)
Natural Fibres, Yarns and Fabrics | Expanding Knowledge in Technology | Management of Solid Waste from Plant Production | Expanding Knowledge in Engineering | Inorganic Industrial Chemicals | Blood Disorders | Synthetic Fibres, Yarns and Fabrics | Organic Industrial Chemicals (excl. Resins, Rubber and Plastics) | Environmentally Sustainable Manufacturing not elsewhere classified
Related Links
Publications
Synthesis and preliminary investigations into norbornane-based amphiphiles and their self-assembly
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3NJ00145H
Thermo-responsive PNIPAM nanofibres crosslinked by OpePOSS
Publisher: SPIE
Date: 09-08-2013
DOI: 10.1117/12.2021556
A simple and effective method to ameliorate the interfacial properties of cellulosic fibre based bio-composites using poly (ethylene glycol) based amphiphiles
Publisher: Elsevier BV
Date: 03-2015
Efficient Bayesian Function Optimization of Evolving Material Manufacturing Processes
Publisher: American Chemical Society (ACS)
Date: 18-11-2019
Improving the Tensile Properties of Wet Spun Silk Fibers Using Rapid Bayesian Algorithm
Publisher: American Chemical Society (ACS)
Date: 09-04-2020
Norbornene chaotropic salts as low molecular mass ionic organogelators (LMIOGs)
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC01798K
Abstract: A humble norbornene functions as an ionic organogelator, forms aqueous biphasic and triphasic systems and assembles to form chiral helices.
Thermo-responsive Hercosett/Poly(N-isopropylacrylamide) films: a new, fast, optically responsive coating.
Publisher: Elsevier BV
Date: 03-2012
DOI: 10.1016/J.JCIS.2011.11.035
Abstract: Poly(N-isopropylacrylamide) (PNIPAM) is a common thermo-responsive, water-soluble polymer, while Hercosett is a cationic resin commonly employed in the paper industry. In this paper, Hercosett™ and poly(N-isopropylacrylamide) (PNIPAM) nanoparticles were used to prepare composite films that show thermo-responsive behavior and swelling-shrinking properties in water. First, size-controlled PNIPAM hydrogel nanoparticles were synthesized. These were then embedded within a matrix of the cationic resin Kymene 577H by film casting. The distribution of nanoparticles in the resin film was investigated. The thermo-responsive properties of the as-synthesized PNIPAM hydrogel nanoparticles and of the composite films were characterized together with the repeatability of the swelling-shrinking cycles. The presence of nanoparticles endowed the film with highly enhanced water retention (in comparison with resin-only films) and, most importantly, thermo-responsiveness. A very fast optical and morphological response was in fact observed. Due to the dual (optical and morphological) response, this new system is suitable for applications in optical or morphological actuation and gating.
Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology
Publisher: ALTEX Edition
Date: 2015
Abstract: Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.
Flux-Assisted Self-Assembly of Monodisperse Colloids
Publisher: American Chemical Society (ACS)
Date: 07-08-2003
DOI: 10.1021/LA034485R
Critical effects of polar fluorescent probes on the interaction of DHA with POPC supported lipid bilayers
Publisher: Elsevier BV
Date: 05-2018
DOI: 10.1016/J.BBAMEM.2018.01.013
Abstract: The understanding of lipid bilayer structure and function has been advanced by the application of molecular fluorophores. However, the effects of these probe molecules on the physicochemical properties of membranes being studied are poorly understood. A quartz crystal microbalance with dissipation monitoring instrument was used in this work to investigate the impact of two commonly used fluorescent probes, 1‑palmitoyl‑2‑{12‑[(7‑nitro‑2‑1,3‑benzoxadiazol‑4‑yl)amino]dodecanoyl}‑sn‑glycero‑3‑phosphocholine (NBD-PC) and 1,2‑dipalmitoyl‑sn‑glycero‑3‑phosphoethanolamine‑n‑(lissamine rhodamine‑B‑sulfonyl) (Lis-Rhod PE), on the formation and physicochemical properties of a 1‑palmitoyl‑2‑oleoyl‑sn‑glycero‑3‑phosphocholine supported lipid bilayer (POPC-SLB). The interaction of the POPC-SLB and fluorophore-modified POPC-SLB with docosahexaenoic acid, DHA, was evaluated. The incorporation of DHA into the POPC-SLB was observed to significantly decrease in the presence of the Lis-Rhod PE probe compared with the POPC-SLB. In addition, it was observed that the small concentration of DHA incorporated into the POPC:NBD-PC SLB can produce rearrangement processes followed by the lost not only of DHA but also of POPC or NBD-PC molecules or both during the washing step. This work has significant implications for the interpretation of data employing fluorescent reporter molecules within SLBs.
Inverse opal gas sensors: Zn(II)-doped tin dioxide systems for low temperature detection of pollutant gases
Publisher: Elsevier BV
Date: 14-03-2008
Fast responsive and morphologically robust thermo-responsive hydrogel nanofibres from poly(N-isopropylacrylamide) and POSS crosslinker
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1SM00010A
Inverse Opal Nanoassemblies: Novel Architectures for Gas Sensors The SnO2:Zn Case
Publisher: Springer Science and Business Media LLC
Date: 2006
Abstract: A novel technique is here presented, based on inverse opal metal oxide structures for the production of high quality macro and meso-porous structures for gas sensing. Taking advantage of a sol-gel templated approach, different mixed semiconducting oxides with high surface area, commonly used in chemical sensing application, were synthesized. In this work we report the comparison between SnO2 and SnO2:Zn. As witnessed by Scanning and Transmission Electron Microscopy (SEM and TEM) analyses and by Powder x-ray Diffraction (PXRD), highly ordered meso-porous structures were formed with oxide crystalline size never exceeding 20 nm. The filled templates, in form of thick films, were bound to allumina substrate with Pt interdigitated contacts and Pt heater, through in situ calcination,in order to perform standard electrical characterization. Pollutant gases like CO and NO2 and methanol, as interfering gas, were used for the targeted electrical gas tests. All s les showed low detection limits towards both reducing and oxidizing species in low temperature measurements. Moreover, the addiction of high molar percentages of Zn(II) affected the behaviour of electrical response improving the selectivity of the proposed system.
Biofunctionalization of 3D Nylon 6,6 Scaffolds Using a Two-Step Surface Modification
Publisher: American Chemical Society (ACS)
Date: 04-06-2012
DOI: 10.1021/AM300087K
Abstract: Nylon is a relatively inert polymer. The ability to easily functionalize nylon with biomolecules will improve the utilization of nylon in biological systems. A potential use of the biofunctionalized nylon scaffolds is in devices for cell therapeutics that can specifically select cells present in small numbers, such as hematopoietic stem cells. This study developed a versatile and simple two-step technique combining oxygen plasma treatment with wet silanization to graft biomolecules onto nylon 6,6 3D porous scaffolds. Scaffolds that were exposed to oxygen plasma exhibited up to 13-fold increase in silane attachment ((3-mercaptopropyl)trimethoxysilane/(3-aminopropyl)trimethoxysilane) compared to untreated scaffolds. To address the limitation of nondestructive characterization of the surface chemistry of 3D scaffolds, fluorescent CdSe/ZnS nanoparticles were used as a reporting tool for -NH2 functionalized surfaces. Scaffolds that were covalently bound with neutravidin protein remained stable in phosphate buffered saline up to four months. Functionality of the neutravidin-grafted scaffolds was demonstrated by the specific binding of CD4 cells to the scaffold via CD4-specific antibody. Ultimately, these neutravidin-functionalized 3D nylon scaffolds could be easily customized on demand utilizing a plethora of biotinylated biomolecules (antibodies, enzymes and proteins) to select for specific cell of interest. This technique can be extended to other applications, including the enhancement of cell-scaffold interactions.
A new way to nanostructure hydrogels: Electrospun thermo-responsive islands-in-the-sea nanofibres
Publisher: Springer Science and Business Media LLC
Date: 2012
DOI: 10.1557/OPL.2012.418
Abstract: An effective strategy to produce thermo-responsive islands-in-the-sea hydrogel nanofibres was developed using a single needle electrospinning setup. The produced hydrogel nanofibre mats not only showed excellent temperature response and high response speed, but also showed nanostructured surfaces.
Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods
Publisher: ALTEX Edition
Date: 2012
DOI: 10.14573/ALTEX.2012.4.373
Abstract: Several alternative methods to replace animal experiments have been accepted by legal bodies. An even larger number of tests are under development or already in use for non-regulatory applications or for the generation of information stored in proprietary knowledge bases. The next step for the use of the different in vitro methods is their combination into integrated testing strategies (ITS) to get closer to the overall goal of predictive "in vitro-based risk evaluation processes." We introduce here a conceptual framework as the basis for future ITS and their use for risk evaluation without animal experiments. The framework allows incorporation of both in idual tests and already integrated approaches. Illustrative ex les for elements to be incorporated are drawn from the session "Innovative technologies" at the 8th World Congress on Alternatives and Animal Use in the Life Sciences, held in Montreal, 2011. For instance, LUHMES cells (conditionally immortalized human neurons) were presented as an ex le for a 2D cell system. The novel 3D platform developed by InSphero was chosen as an ex le for the design and use of scaffold-free, organotypic microtissues. The identification of critical pathways of toxicity (PoT) may be facilitated by approaches exemplified by the MatTek 3D model for human epithelial tissues with engineered toxicological reporter functions. The important role of in silico methods and of modeling based on various pre-existing data is demonstrated by Altamira's comprehensive approach to predicting a molecule's potential for skin irritancy. A final ex le demonstrates how natural variation in human genetics may be overcome using data analytic (pattern recognition) techniques borrowed from computer science and statistics. The overall hazard and risk assessment strategy integrating these different ex les has been compiled in a graphical work flow.
Understanding<i> In Vivo</i> Abrasion Fatigue of Common Suture Materials Used in Arthroscopic and Open Shoulder Surgery
Publisher: Trans Tech Publications Ltd
Date: 11-09-2012
DOI: 10.4028/WWW.SCIENTIFIC.NET/AST.86.34
Abstract: In orthopaedic surgery the reattachment of tendon to bone requires suture materials that have stable and durable properties to allow healing at the tendon-bone interface. Failure rates of this type of surgery can be as high as 25%. While the tissue suture interface is a weak link, proportions of these failures are caused by in-vivo abrasion of the suture with bone and suture anchor materials. Abrasion of the suture material results from the movement of the suture through the eyelet by the surgeon during surgery, or with limb movement after surgery as the suture is not rigidly restrained within the eyelet. During movement the suture is subjected to bending and frictional forces that can lead to fatigue induced failure. This paper investigates the mechanism of bending abrasion fatigue induced failure of number two grade braided sheath only and braided sheath/multifilament core sutures. Sutures were oscillated over a stainless steel wire at low frequency under load in a dry state to simulate the bending and frictional forces between suture and eyelet. Failure mechanism was determined by video microscopy of the suture during abrasion combined with optical microscopy analysis of partially and fully abraded sutures. Braided only structures had high friction loading on the small number of fibres at the abrasion interface. This caused rapid single fibre breakages that accumulate to cause suture failure. The addition of ultra-high molecular weight polyethylene core fibres to a braided suture distributed the applied load across multiple fibres at the abrasion interface. This improved abrasion resistance by 15-20 times that of braided sheath alone.
Optimizing a High-Entropy System: Software-Assisted Development of Highly Hydrophobic Surfaces using an Amphiphilic Polymer
Publisher: American Chemical Society (ACS)
Date: 23-09-2019
Nano-capsules of amphiphilic poly(ethylene glycol)-block-poly(bisphenol A carbonate) copolymers via thermodynamic entrapment
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5RA23555C
Abstract: Fast and simple preparation of nano-capsules by water addition to poly(ethylene glycol)- block -poly(bisphenol A carbonate) copolymers in THF.
Phase Transition of Poly(N-isopropylacrylamide) in Aqueous Protic Ionic Liquids: Kosmotropic versus Chaotropic Anions and Their Interaction with Water
Publisher: American Chemical Society (ACS)
Date: 08-07-2013
DOI: 10.1021/JP4043232
Abstract: We have investigated the influence of a series of triethylammonium-based protic ionic liquid-water solutions on the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM). We find that kosmotropic anions lower the LCST of PNIPAM more dramatically when compared with chaotropic anions. In addition, we have probed the solvent properties of the hydrated protic ionic liquid solutions using (1)H NMR, polarity measurements, and solvatochromic analysis of the Kamlet-Taft parameters, β and π*. We find that the hydrogen bond character--more specifically, the interactions between water and pIL--is the dominant parameter responsible for lowering the LCST of PNIPAM. We have added choline dihydrogen phosphate (choline dhp) into this study on the basis of positive results from previously reported protein folding studies using this ionic liquid.
Temperature-Responsive Self-Assemblies of ‘Kinked' Amphiphiles
Publisher: CSIRO Publishing
Date: 2013
DOI: 10.1071/CH13278
Abstract: The synthesis of novel norbornane-based hiphiles and the thermal response of their corresponding colloids is presented. It was found that the hydrodynamic diameter (DH) expansion or contraction of 1–4 in response to increasing temperature was governed by the length of the hydrophobic region possessed by the hiphile (a 12 or 16 carbon chain). These data were used as a starting point to extend into an active tumour targeting system whereby two hiphiles were modified to incorporate the oestrogen receptor antagonist Tamoxifen at the polar head group. This was achieved by a triazole moiety while both the C12 (18) or C16 (19) hydrophobic chains were incorporated as the hydrophobic region in an attempt to retain the response to thermal stimuli observed in our preliminary findings. These functionalised novel hiphiles possessed critical aggregation concentration values of 510 and 19 µM, while aqueous self-assemblies of 56 and 106 nm for 18 and 19 were observed. Imaging by cryogenic transmission electron microscopy showed 18 to possess liposomal morphology, while 19, bearing a C16 hydrophobic portion, formed non-defined amorphous aggregates. Finally, the response to temperature of these assemblies was investigated with only the C12 variant 18 displaying a temperature response in the 5–55°C thermal window investigated.
Enhanced cell growth using non-woven scaffolds of multilobal fibres
Publisher: SAGE Publications
Date: 30-03-2012
Abstract: Multilobal fibres contain several grooves and have higher surface area than round fibres. Cell density can be enhanced when cultured on scaffolds manufactured with multilobal fibres. This study compared the cell growth of dermal fibroblasts and osteoblast-like SaOS2 cells on polymeric scaffolds produced from multilobal fibres to the conventional round-fibred scaffolds. Cells were cultured on round nylon 6,6, trilobal nylon 6,6, round polyethylene terephthalate (PET) and multilobal PET scaffolds for 14 days. There were more cells cultured on trilobal nylon 6,6 and PET multilobal scaffolds than their round counterparts. Preference to the type of multilobal scaffolds was cell dependent. Fibroblasts increased by 21.8 ± 1.9 fold to 6.3 × 10 5 cells ( p 0.001) when cultured on trilobal nylon 6,6 scaffolds while SaOS2 cells exhibited a 16.7 ± 2.8 fold increase (2.9 × 10 5 cells, p 0.001) on the multilobal PET scaffolds after 14 days of culture. The ability of multilobal fibres to accommodate large quantities of cells presents an excellent alternative to round fibres as scaffolds for tissue engineering.
Three-Dimensional Tissue Scaffolds from Interbonded Poly(ε-Caprolactone) Fibrous Matrices with Controlled Porosity
Publisher: Mary Ann Liebert Inc
Date: 02-2011
Bending and abrasion fatigue of common suture materials used in arthroscopic and open orthopedic surgery
Publisher: Wiley
Date: 09-07-2013
DOI: 10.1002/JOR.22185
Abstract: In orthopedic surgery, the reattachment of tendon to bone requires suture materials that have stable and durable properties to allow time for healing at the tendon-bone interface. The suture, not rigidly restrained within the anchor eyelet, is free to move during surgery and potentially after surgery with limb motion. During such movement, the suture is subjected to bending and frictional forces that can lead to fatigue-induced failure. We investigated some common contemporary commercial number-two-grade suture materials and evaluated their resistance to bending abrasion fatigue and the consequent failure. Sutures were oscillated over a stainless steel wire at low frequency under load. Number of abrasion cycles to failure, changes in suture morphology, and fatigue-failure method was recorded for each material. Suture structure had a significant effect on abrasion resistance, with braided sutures containing large numbers of fine high tenacity core filaments performing 15-20 times better than other braided suture structures. Ultra high molecular weight polyethylene (UHMWPE) core filaments resisted bending abrasion failure better than other core materials due to the load spreading and abrasion resistance of these filaments. Sutures with UHMWPE cores also had high resistance to tensile failure. Limited correlation was observed between tensile strength and abrasion resistance.
The effect of metal ligands on the adsorption of metal coordination complexes on polystyrene nano-beads
Publisher: Elsevier BV
Date: 09-2019
Inverse Opal Structure of SnO2 and SnO2: Zn for Gas Sensing
Publisher: IEEE
Date: 2005
Metal ion type significantly affects the morphology but not the activity of lipase–metal–phosphate nanoflowers
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7RA00302A
Abstract: Using different metal ions to prepare hybrid lipase nanoflowers resulted in a variety of different morphologies, but did not significantly affect the specific activity of the enzyme.
Shear-Enhanced Solution Precipitation: A Simple Process to Produce Short Polymeric Nanofibers
Publisher: American Scientific Publishers
Date: 10-2011
Abstract: The growing interest in polymeric nanofibers has been increasing the push for the development of simple and efficient nanofiber-preparation techniques. We herein describe how a conventional solution process is readapted to suit the needs for fast and efficient production of short polymeric nanofibers. Poly(ethylene-co-acrylic acid) (PEAA), a semi-crystalline polymer, was used as model. When a PEAA solution was injected into an alcoholic non-solvent while simultaneously applying high shear to the non-solvent system, PEAA nanofibers were obtained with average diameter as thin as 113 nm and length as short as 4.5 microm. The fiber diameter and length were also adjustable by varying the operating parameters. This one-step technique advances the currently available nanofabrication tools by adjusting a widely accepted concept to the nano-scale. It may constitute a viable method for large-scale production of short polymeric nanofibers. Polymer Nanofibers, Solution Dispersion, Shear-Enhanced Precipitation, Poly(ethylene-co-acrylic acid), Operating Parameters, Short Nanofibers.
Bulk network polymers with dynamic B–O bonds: healable and reprocessable materials
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9MH01223K
Abstract: The recent progress in healable and reprocessable bulk network polymers with dynamic B–O bonds is reviewed.
Accelerating Experimental Design by Incorporating Experimenter Hunches
Publisher: IEEE
Date: 11-2018
Electrospinning of nanofibres with parallel line surface texture for improvement of nerve cell growth
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1SM06430D
Related Organisations
MatTek Corporation (United States)
Location: United States of America
Related Funding Activities
Industrial Transformation Research Hubs - Grant ID: IH210100023
Start Date: 09-2022
End Date: 09-2027
Amount: $5,000,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Projects - Grant ID: LP140100287
Start Date: 02-2015
End Date: 12-2018
Amount: $470,491.00
Funder: Australian Research Council
View Funded ActivityIndustrial Transformation Research Hubs - Grant ID: IH140100018
Start Date: 05-2016
End Date: 05-2021
Amount: $4,711,583.00
Funder: Australian Research Council
View Funded ActivityIndustrial Transformation Training Centres - Grant ID: IC190100034
Start Date: 12-2020
End Date: 12-2025
Amount: $3,574,272.00
Funder: Australian Research Council
View Funded Activity