ORCID Profile
0000-0001-7728-5866
Current Organisations
Deakin University
,
Centre for Innovation, Research and Consultancy
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Publications
Biogenic titanium nanoparticles (TiO2NPs) from Tricoderma citrinoviride extract: synthesis, characterization and antibacterial activity against extremely drug-resistant Pseudomonas aeruginosa
Publisher: Springer Science and Business Media LLC
Date: 13-11-2020
Myco-synthesized silver and titanium oxide nanoparticles as seed priming agents to promote seed germination and seedling growth of Solanum lycopersicum: a comparative study
Publisher: Springer Science and Business Media LLC
Date: 12-06-2021
Prospects of chloroplast metabolic engineering for developing nutrient-dense food crops
Publisher: Informa UK Limited
Date: 11-07-2023
DOI: 10.1080/07388551.2022.2092717
Abstract: Addressing nutritional deficiencies in food crops through biofortification is a sustainable approach to tackling malnutrition. Biofortification is continuously being attempted through conventional breeding as well as through various plant biotechnological interventions, ranging from molecular breeding to genetic engineering and genome editing for enriching crops with various health-promoting metabolites. Genetic engineering is used for the rational incorporation of desired nutritional traits in food crops and predominantly operates through nuclear and chloroplast genome engineering. In the recent past, chloroplast engineering has been deployed as a strategic tool to develop model plants with enhanced nutritional traits due to the various advantages it offers over nuclear genome engineering. However, this approach needs to be extended for the nutritional enhancement of major food crops. Further, this platform could be combined with strategies, such as synthetic biology, chloroplast editing, nanoparticle-mediated rapid chloroplast transformation, and horizontal gene transfer through grafting for targeting endogenous metabolic pathways for overproducing native nutraceuticals, production of biopharmaceuticals, and biosynthesis of designer nutritional compounds. This review focuses on exploring various features of chloroplast genome engineering for nutritional enhancement of food crops by enhancing the levels of existing metabolites, restoring the metabolites lost during crop domestication, and introducing novel metabolites and phytonutrients needed for a healthy daily diet.
Arbuscular mycorrhizal (Glomus fasciculatum) fungi as a plant immunity booster against fungal pathogen
Publisher: Enviro Research Publishers
Date: 05-01-2019
DOI: 10.12944/CARJ.7.1.12
Abstract: Reactive Oxygen Species (ROS) mediated immune response in tomato (Solanum lycopersicum) plants inoculated with arbuscular mycorrhizal fungi (AMF) Glomus fasciculatum (GF) was studied in the presence of plant pathogenic fungi Fusarium oxysporum f. sp. lycopersici (FOL). Our aim was to assess how symbiosis of AMF potentiates ROS immune response system to deal pathogen mediated biotic stress. Tomato plant was inoculated with GF, FOL and GF + FOL in separate experimental sets to examine its effect on plants ROS machinery and the time taken to alleviate biotic stress. The antioxidant response was evaluated and correlated with the time provided by GF treated plants against FOL to initiate their second line of defenses as compared to only FOL treated ones. The establishment of symbiosis and development showed a positive effect on plant ROS response system and subsequently its growth. No significant difference was seen in the root mass of only GF, FOL and GF + FOL. The increase in activities of superoxide dismutase, catalase and peroxidase was similar in all the control and treated plants however reduction in activities of these ROS scavengers was much faster in GF supplemented plants. Similar trend was also observed for ROS radicals possibly due to the involvement of antioxidant enzymes. LC-MS analysis of FOL was performed to co-relate the effect of some dominant compounds with its pathogenicity. Therefore, our results showcase AMF-GF’s ability to alleviate the oxidative damage generated by biotic stress and highlights on the buffer time taken by plants defense machinery to immunize itself at various levels.
Bacterial Membrane Mimetics: From Biosensing to Disease Prevention and Treatment
Publisher: MDPI AG
Date: 26-01-2023
DOI: 10.3390/BIOS13020189
Abstract: Plasma membrane mimetics can potentially play a vital role in drug discovery and immunotherapy owing to the versatility to assemble facilely cellular membranes on surfaces and/or nanoparticles, allowing for direct assessment of drug/membrane interactions. Recently, bacterial membranes (BMs) have found widespread applications in biomedical research as antibiotic resistance is on the rise, and bacteria-associated infections have become one of the major causes of death worldwide. Over the last decade, BM research has greatly benefited from parallel advancements in nanotechnology and bioelectronics, resulting in multifaceted systems for a variety of sensing and drug discovery applications. As such, BMs coated on electroactive surfaces are a particularly promising label-free platform to investigate interfacial phenomena, as well as interactions with drugs at the first point of contact: the bacterial membrane. Another common approach suggests the use of lipid-coated nanoparticles as a drug carrier system for therapies for infectious diseases and cancer. Herein, we discuss emerging platforms that make use of BMs for biosensing, bioimaging, drug delivery/discovery, and immunotherapy, focusing on bacterial infections and cancer. Further, we detail the synthesis and characteristics of BMs, followed by various models for utilizing them in biomedical applications. The key research areas required to augment the characteristics of bacterial membranes to facilitate wider applicability are also touched upon. Overall, this review provides an interdisciplinary approach to exploit the potential of BMs and current emerging technologies to generate novel solutions to unmet clinical needs.
Hypoglycemic and anticataract activity of crude exopolysaccharides of medicinal mushroom Phellinus badius on streptozotocin-induced diabetic rats and goat eye lenses respectively
Publisher: Elsevier BV
Date: 10-2020
A Short History and Perspectives on Plant Genetic Transformation
Publisher: Springer US
Date: 2020
Vanilla modulates the activity of antibiotics and inhibits efflux pumps in drug-resistant Pseudomonas aeruginosa
Publisher: Springer Science and Business Media LLC
Date: 04-11-2020
Designer nanoparticles for plant cell culture systems: Mechanisms of elicitation and harnessing of specialized metabolites
Publisher: Wiley
Date: 04-10-2021
Abstract: Plant cell culture systems have become an attractive and sustainable approach to produce high‐value and commercially significant metabolites under controlled conditions. Strategies involving elicitor supplementation into plant cell culture media are employed to mimic natural conditions for increasing the metabolite yield. Studies on nanoparticles (NPs) that have investigated elicitation of specialized metabolism have shown the potential of NPs to be a substitute for biotic elicitors such as phytohormones and microbial extracts. Customizable physicochemical characteristics allow the design of monodispersed‐, stimulus‐responsive‐, and hormone‐carrying‐NPs of precise geometries to enhance their elicitation capabilities based on target metabolite lant cell culture type. We contextualize advances in NP‐mediated elicitation, especially stimulation of specialized metabolic pathways, the underlying mechanisms, impacts on gene regulation, and NP‐associated cytotoxicity. The novelty of the concept lies in unleashing the potential of designer NPs to enhance yield, harness metabolites, and transform nanoelicitation from exploratory investigations to a commercially viable strategy.
Related Organisations
Related Funding Activities
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