ORCID Profile
0000-0003-4581-2750
Current Organisations
Royal Hobart Hospital
,
Deakin University
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Publisher: IEEE
Date: 07-2017
Publisher: Wiley
Date: 11-2021
DOI: 10.1111/IMJ.15566
Publisher: IEEE
Date: 04-2018
Publisher: Elsevier BV
Date: 12-2021
DOI: 10.1016/J.CLCC.2021.06.003
Abstract: The optimal management of isolated distant lymph node metastases (IDLNM) from a colorectal primary, is not clearly established. We aimed to analyze the outcomes of patients with IDLNM treated with systemic therapies plus locoregional therapy with curative intent versus systemic therapies with palliative intent. Clinical data were collected and reviewed from the Treatment of Recurrent and Advanced Colorectal Cancer registry, a prospective, comprehensive registry for metastatic colorectal cancer (mCRC) treated at multiple tertiary hospitals across Australia. Clinicopathological characteristics, treatment modalities and survival outcomes were analyzed in patients with IDLNM and compared to patients with disease at other sites. Of 3408 mCRC patients diagnosed 2009 to 2020, with median follow-up of 38.0 months, 93 (2.7%) were found to have IDLNM. Compared to mCRC at other sites, patients with IDLNM were younger (mean age: 62.1 vs. 65.6 years, P = .02), more likely to have metachronous disease (57.0% vs. 38.9%, P < .01), be KRAS wild-type (74.6% vs. 53.9%, P< .01) and BRAF mutant (12.9% vs. 6.2%, P = .01). Amongst mCRC patients with IDLNM, 24 (25.8%) received treatment with curative intent and had a significantly better overall median survival than those treated with palliative intent (73.5 months vs. 23.2 months, P = .01). These 24 patients had an overall median survival similar (62.7 months, P = .82) to patients with isolated liver or lung metastases also treated with curative intent. Curative treatment strategies (radiotherapy or surgery), with or without systemic therapy, should be considered for mCRC patients with IDLNM where appropriate as assessed by the multidisciplinary team.
Publisher: MDPI AG
Date: 20-12-2017
DOI: 10.3390/E19120697
Publisher: IEEE
Date: 07-2019
Publisher: IEEE
Date: 08-2016
Publisher: IEEE
Date: 07-2018
Publisher: MDPI AG
Date: 20-12-2019
DOI: 10.3390/BIOS10010001
Abstract: In this paper, we have investigated the differences in the voices of Parkinson’s disease (PD) and age-matched control (CO) subjects when uttering three phonemes using two complexity measures: fractal dimension (FD) and normalised mutual information (NMI). Three sustained phonetic voice recordings, /a/, /u/ and /m/, from 22 CO (mean age = 66.91) and 24 PD (mean age = 71.83) participants were analysed. FD was first computed for PD and CO voice recordings, followed by the computation of NMI between the test groups: PD–CO, PD–PD and CO–CO. Four features reported in the literature—normalised pitch period entropy (Norm. PPE), glottal-to-noise excitation ratio (GNE), detrended fluctuation analysis (DFA) and glottal closing quotient (ClQ)—were also computed for comparison with the proposed complexity measures. The statistical significance of the features was tested using a one-way ANOVA test. Support vector machine (SVM) with a linear kernel was used to classify the test groups, using a leave-one-out validation method. The results showed that PD voice recordings had lower FD compared to CO (p 0.008). It was also observed that the average NMI between CO voice recordings was significantly lower compared with the CO–PD and PD–PD groups (p 0.036) for the three phonetic sounds. The average NMI and FD demonstrated higher accuracy ( %) in differentiating the test groups compared with other speech feature-based classifications. This study has demonstrated that the voices of PD patients has reduced FD, and NMI between voice recordings of PD–CO and PD–PD is higher compared with CO–CO. This suggests that the use of NMI obtained from the s le voice, when paired with known groups of CO and PD, can be used to identify PD voices. These findings could have applications for population screening.
Publisher: IEEE
Date: 05-2014
No related grants have been discovered for Adrian Bingham.