ORCID Profile
0000-0003-2015-6419
Current Organisation
University of Tasmania
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Geology | Volcanology | Natural hazards | Sedimentology | Geophysics | Volcanology | Sedimentology | Marine Geoscience | Geology | Igneous and Metamorphic Petrology | Geodynamics
Expanding Knowledge in the Earth Sciences | Copper Ore Exploration | Mineral Resources (excl. Energy Resources) not elsewhere classified | Zinc Ore Exploration | Precious (Noble) Metal Ore Exploration | Mineral Exploration not elsewhere classified |
Publisher: Frontiers Media SA
Date: 17-10-2018
Publisher: Springer Science and Business Media LLC
Date: 08-05-2017
Publisher: Wiley
Date: 27-02-2015
Publisher: Elsevier BV
Date: 2019
Publisher: Springer Science and Business Media LLC
Date: 03-2007
Publisher: Wiley
Date: 27-02-2015
Publisher: Springer Science and Business Media LLC
Date: 22-04-2014
DOI: 10.1038/NCOMMS4660
Abstract: Pumice rafts are floating mobile accumulations of low-density pumice clasts generated by silicic volcanic eruptions. Pumice in rafts can drift for years, become waterlogged and sink, or become stranded on shorelines. Here we show that the pumice raft formed by the impressive, deep submarine eruption of the Havre caldera volcano (Southwest Pacific) in July 2012 can be mapped by satellite imagery augmented by sailing crew observations. Far from coastal interference, the eruption produced a single km 2 raft in 1 day, thus initiating a gigantic, high-precision, natural experiment relevant to both modern and prehistoric oceanic surface dispersal dynamics. Observed raft dispersal can be accurately reproduced by simulating drift and dispersal patterns using currents from an eddy-resolving ocean model hindcast. For future eruptions that produce potentially hazardous pumice rafts, our technique allows real-time forecasts of dispersal routes, in addition to inference of ash umice deposit distribution in the deep ocean.
Publisher: Springer Science and Business Media LLC
Date: 06-09-2016
Publisher: Geological Society of America
Date: 22-03-2019
DOI: 10.1130/G45657.1
Publisher: Geological Society of America
Date: 04-2010
DOI: 10.1130/G30573.1
Publisher: Springer Science and Business Media LLC
Date: 04-04-2006
Publisher: Elsevier BV
Date: 05-2018
Publisher: Geological Society of America
Date: 09-11-2018
DOI: 10.1130/G45436.1
Publisher: Elsevier BV
Date: 03-2008
Publisher: Elsevier BV
Date: 10-2023
Publisher: Elsevier BV
Date: 2015
Publisher: American Association for the Advancement of Science (AAAS)
Date: 05-01-2018
Abstract: A submersible study of the products of a large submarine eruption demonstrates the influence of the ocean on eruption dynamics.
Publisher: Elsevier BV
Date: 05-2013
Publisher: American Geophysical Union (AGU)
Date: 02-03-2020
DOI: 10.1029/2019GL086768
Publisher: Elsevier BV
Date: 07-2009
Publisher: Cold Spring Harbor Laboratory
Date: 30-11-2016
Abstract: Chromosomal translocations are a genomic hallmark of many hematologic malignancies. Often as initiating events, these structural abnormalities result in fusion proteins involving transcription factors important for hematopoietic differentiation and/or signaling molecules regulating cell proliferation and cell cycle. In contrast, epigenetic regulator genes are more frequently targeted by somatic sequence mutations, possibly as secondary events to further potentiate leukemogenesis. Through comprehensive whole-transcriptome sequencing of 231 children with acute lymphoblastic leukemia (ALL), we identified 58 putative functional and predominant fusion genes in 54.1% of patients ( n = 125), 31 of which have not been reported previously. In particular, we described a distinct ALL subtype with a characteristic gene expression signature predominantly driven by chromosomal rearrangements of the ZNF384 gene with histone acetyltransferases EP300 and CREBBP . ZNF384 -rearranged ALL showed significant up-regulation of CLCF1 and BTLA expression, and ZNF384 fusion proteins consistently showed higher activity to promote transcription of these target genes relative to wild-type ZNF384 in vitro. Ectopic expression of EP300 - ZNF384 and CREBBP - ZNF384 fusion altered differentiation of mouse hematopoietic stem and progenitor cells and also potentiated oncogenic transformation in vitro. EP300- and CREBBP-ZNF384 fusions resulted in loss of histone lysine acetyltransferase activity in a dominant-negative fashion, with concomitant global reduction of histone acetylation and increased sensitivity of leukemia cells to histone deacetylase inhibitors. In conclusion, our results indicate that gene fusion is a common class of genomic abnormalities in childhood ALL and that recurrent translocations involving EP300 and CREBBP may cause epigenetic deregulation with potential for therapeutic targeting.
Publisher: Elsevier
Date: 2015
Publisher: Elsevier BV
Date: 07-2018
Publisher: Geological Society of America
Date: 05-2014
DOI: 10.1130/G35400.1
Publisher: Elsevier BV
Date: 09-2004
Publisher: Springer Science and Business Media LLC
Date: 24-07-2014
Publisher: Elsevier BV
Date: 06-2011
Publisher: Elsevier BV
Date: 07-2017
Publisher: Geological Society of America
Date: 06-2013
DOI: 10.1130/G34146.1
Publisher: American Geophysical Union (AGU)
Date: 06-11-2019
DOI: 10.1029/2019GL084031
Abstract: On behalf of the journal, AGU, and the scientific community, the Editors would like to sincerely thank those who reviewed manuscripts for Geophysical Research Letters in 2018. The hours reading and commenting on manuscripts not only improves the manuscripts but also increases the scientific rigor of future research in the field. We particularly appreciate the timely reviews, in light of the demands imposed by the rapid review process at Geophysical Research Letters . With the revival of the “major revisions” decisions, we appreciate the reviewers' efforts on multiple versions of some manuscripts. Many of those listed below went beyond and reviewed three or more manuscripts for our journal, and those are indicated in italics. In total, 4,484 referees contributed to 7,557 in idual reviews in journal. Thank you again. We look forward to the coming year of exciting advances in the field and communicating those advances to our community and to the broader public.
Publisher: American Geophysical Union (AGU)
Date: 11-2012
DOI: 10.1029/2012JB009496
Publisher: Geological Society of America
Date: 03-2011
DOI: 10.1130/G31509.1
Publisher: Elsevier BV
Date: 05-2018
Publisher: Frontiers Media SA
Date: 23-01-2019
Publisher: Springer Science and Business Media LLC
Date: 27-04-2021
Publisher: Geological Society of America
Date: 07-01-2016
DOI: 10.1130/G37423.1
Publisher: Informa UK Limited
Date: 16-03-2023
Publisher: Springer Science and Business Media LLC
Date: 24-11-2014
DOI: 10.1038/NI.2769
Publisher: Geological Society of America
Date: 05-2019
DOI: 10.1130/G46033C.1
Publisher: American Society for Microbiology
Date: 05-2015
Abstract: Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persisted in the health care setting for decades, but the basis of its success has not been identified. Taking a collection of 123 ST239 isolates spanning 32 years, we have used population-based functional genomics to investigate the evolution of this highly persistent and successful clone. Phylogenetic reconstruction and population modeling uncovered a previously unrecognized distinct clade of ST239 that was introduced into Australia from Asia and has perpetuated the epidemic in this region. Functional analysis demonstrated attenuated virulence and enhanced resistance to last-line antimicrobials, the result of two different phenomena, adaptive evolution within the original Australian ST239 clade and the introduction of a new clade displaying shifts in both phenotypes. The genetic ersity between the clades allowed us to employ genome-wide association testing and identify mutations in other essential regulatory systems, including walKR , that significantly associate with and may explain these key phenotypes. The phenotypic convergence of two independently evolving ST239 clades highlights the very strong selective pressures acting on HA-MRSA, showing that hospital environments have favored the accumulation of mutations in essential MRSA genes that increase resistance to antimicrobials, attenuate virulence, and promote persistence in the health care environment. Combinations of comparative genomics and careful phenotypic measurements of longitudinal collections of clinical isolates are giving us the knowledge to intelligently address the impact of current and future antibiotic usage policies and practices on hospital pathogens globally. IMPORTANCE Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for innumerable drug-resistant health care-associated infections globally. This study, the first to investigate the evolutionary response of hospital-associated MRSA (HA-MRSA) over many decades, demonstrates how MRSA can persist in a region through the reintroduction of a previously unrecognized distinct clade. This study also demonstrates the crucial adaptive responses of HA-MRSA to the highly selective environment of the health care system, the evolution of MRSA isolates to even higher levels of antibiotic resistance at the cost of attenuated virulence. However, in vivo persistence is maintained, resulting in a clone of HA-MRSA able to resist almost all antimicrobial agents and still cause invasive disease in the heavily compromised hosts found in modern health care settings.
Publisher: Springer Science and Business Media LLC
Date: 09-10-2010
Publisher: Geological Society of America
Date: 04-0004
DOI: 10.1130/G33685.1
Publisher: Elsevier BV
Date: 03-2008
Publisher: American Geophysical Union (AGU)
Date: 08-04-2019
DOI: 10.1029/2018GL081609
Publisher: Elsevier BV
Date: 08-2010
Start Date: 2017
End Date: 2020
Funder: Marsden Fund
View Funded ActivityStart Date: 03-2015
End Date: 12-2020
Amount: $350,259.00
Funder: Australian Research Council
View Funded ActivityStart Date: 11-2020
End Date: 12-2024
Amount: $549,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 10-2023
End Date: 10-2026
Amount: $475,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 11-2011
End Date: 10-2014
Amount: $280,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 04-2020
End Date: 12-2023
Amount: $499,824.00
Funder: Australian Research Council
View Funded Activity