ORCID Profile
0000-0001-7094-0813
Current Organisation
College of Pharmacy, Umm Al-Qura University
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Publisher: Informa UK Limited
Date: 05-2022
DOI: 10.2147/AMEP.S355950
Publisher: Elsevier BV
Date: 05-2023
Publisher: Elsevier BV
Date: 06-2022
Publisher: Walter de Gruyter GmbH
Date: 2023
Abstract: Nanocomposite films have been prepared from chitosan, cinnamaldehyde, Nigella sativa or blackseed oil, and silver nanoparticles (NPs) biosynthesized in Azadirachta indica or neem leaves’ extract. The methodology involved simple blending of components through “green chemistry” route. The films obtained were soft and foldable. The morphology by scanning electron microscopy confirmed the inclusion of NPs in the films. Microbial penetration study demonstrated that the films offered good resistance to secondary bacterial infection. The antibacterial study against Staphylococcus aureus (ATCC 29213) and E. coli (ATCC 25922) indicated moderate antibacterial behavior of the films. The swelling behavior in water, phosphate buffer saline, and simulated wound fluid was found to be appropriate for use as wound dressings. The films were biodegradable in soil and showed good thermal stability up to 200°C.
Publisher: MDPI AG
Date: 26-02-2023
DOI: 10.3390/LIFE13030651
Abstract: Many species belonging to the genus Ocimum are used for aromatic, medicinal, and cosmetic purposes. The essential oil (OFEO) obtained by hydrodistillation of the flowering aerial parts of Forsskal’s Basil “Ocimum forskolei Benth” growing in extreme environmental conditions in Mecca Region, Saudi Arabia was analyzed by GC-MS. The main constituents were phenylpropanoids (methyl eugenol 55.65% and eugenol 11.66%), monoterpene (linalool 9.75%), and sesquiterpenes (germacrene D 3.72% and β-caryophyllene 2.57%). The OFEO was tested against MCF7, HT29, and HCT116 cancer cells and compared with normal fibroblast cells (MRC5). The MTT assay showed that HCT116 was more sensitive to OFEO (IC50 5.34 μg/mL), which reduced the number of HCT116 colonies at 6 μg/mL, while causing complete colony death at 12 and 24 μg/mL. Western Blotting and qRT-PCR were used to evaluate the level change of different proteins with respect to GAPDH. OFEO upregulated the apoptotic protein (caspase 3), and downregulated the cell proliferation proteins (AKT and pAKT), cell cycle arrest (PCNA, Cyclin D1), and the anti-apoptotic Bcl2 proteins. OFEO was also tested against reference strains of Gram-negative and Gram-positive bacteria including Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, and Staphylococcus aureus by using the well-diffusion and assessing their MICs, which ranged from 250 to 500 μg/mL.
Publisher: Author Gate Publications
Date: 30-12-2022
DOI: 10.37881/JMAHS.123
Abstract: Background: Otitis media (OM) is a common inflammatory disease of the middle ear and mostly affects children less than 5 years. It is ided into several disease subcategories: acute otitis media (AOM), recurrent AOM, OM with effusion (OME), and chronic otitis media (COM). This study aims to determine the otitis media and identify the manner of prescribing antibiotics used for the treatment of OM cases in children from 3 months to 5 years old in Hera General hospital in Makkah city. Methods: The s les were retrospectively conducted at a tertiary General Hospital in the western region of Saudi Arabia. 113 records met the inclusion criteria for the study. Data were analyzed using descriptive statistics (percent and frequency). For quantitative data, the chi-square test and mean were used. Results: The number of OM cases was higher in patients aged 3 years old and less among age categories. The percentage of males (54.6%) was higher than females (45.4%). Amoxicillin-clavulanate was the most used treatment of OM in the inpatient ward, outpatient, emergency, and after discharge. The protocol of treatment was mostly by prescribing both antibiotics and analgesics without requesting any further s les to investigate the type of pathogen related to this infection. Cases presented to the emergency department were discharged with an antibiotic prescription without further investigation of the records for previous infection or recurrence. Conclusions: Due to increasing the antibiotics resistance alert around the globe, we believe that OM recurrence could be one of the community-acquired infections that affect the pediatric population and lower the quality of life and need specific attention from a physician who prescribes antibiotics for OM without further investigation.
Publisher: Elsevier BV
Date: 09-2020
Publisher: Frontiers Media SA
Date: 09-01-2023
DOI: 10.3389/FPUBH.2022.1026252
Abstract: Vaccine distrust and rejection are thought to contribute to disease outbreaks and increased mortality. The present study aimed to analyze the socio-cultural characteristics and attitudes of the Saudi population toward vaccines, using a cross-sectional survey-based approach. An online questionnaire was used, following the snowball method. A total of 444 people responded, of whom 333 (75%) were female, and 111 (25%) were male. The demographic characteristics associated with vaccine confidence were gender, job type, medical problems, and knowledge of coronavirus disease 2019 (COVID-19) symptoms. The hesitancy was highest (31.17%) among in iduals aged 21–30 years old, and in more males (27.03%) expressed hesitancy than females (25.23%). However, if we focused on the percentage of the refusal to receive the vaccine, more females (15.23%) refused the vaccine than males (4.5%). More than one-third of the vaccine-hesitant respondents had limited knowledge of COVID-19 symptoms. Personal characteristics associated with vaccine confidence were described as the following: do not fully trust vaccines produced in a short time (42.1%), fear of the future results of the vaccine (30.4%), reluctance to allow a foreign material to enter the body (17.6%), no interaction with others, so no need for the vaccine (11.5%), low interaction with people (67.8%), and reluctance to make decisions (11.3%). The primary social motivation for getting the vaccine was to get back to normal life (67.6%). The results of the present study revealed that more than half of the respondents in Saudi Arabia were confident about the vaccine (61.7%), while only 25.7% were hesitant and 12.6% were unconvinced. Based on these results, in the early period of COVID-19 vaccine administration in the country (early 2021), before any governmental allowance and political intervention, we found that the socio-demographic and socio-cultural characteristics of the population were significant factors contributing to vaccination acceptance. Therefore, policymakers should support long-term safety studies of the vaccine, conduct educational programs giving high-priority to the populations' health, and tailor vaccination hesitancy reduction techniques to local communities.
Publisher: MDPI AG
Date: 18-03-2022
DOI: 10.3390/ANTIBIOTICS11030409
Abstract: Background: The clinical significance of utilizing a vancomycin loading dose in critically ill patients remains unclear. Objective: The main aim of this systematic review is to evaluate the clinical safety and efficacy of the vancomycin loading dose in critically ill patients. Methods: We performed a systematic review using PRISMA guidelines. PubMed, the Web of Science, MEDLINE, Scopus, Google Scholar, the Saudi Digital Library and other databases were searched. Studies that reported clinical outcomes among patients receiving the vancomycin LD were considered eligible. Data for this study were collected using PubMed, the Web of Science, MEDLINE, Scopus, Google Scholar and the Saudi Digital Library using the following terms: “vancomycin”, “safety”, “efficacy” and “loading dose” combined with the Boolean operator “AND” or “OR”. Results: A total of 17 articles, including 2 RCTs, 11 retrospective cohorts and 4 other studies, met the inclusion/exclusion criteria out of a total 1189 studies. Patients had different clinical characteristics representing a heterogenous group, including patients in critical condition, with renal impairment, sepsis, MRSA infection and hospitalized patients for hemodialysis or in the emergency department. Conclusions: The study shows that the target therapeutic level is achieved more easily among patients receiving a weight-based LD as compared to patients received the usual dose without an increased risk of new-onset adverse drug reactions.
Publisher: Informa UK Limited
Date: 30-03-2022
Publisher: Springer Science and Business Media LLC
Date: 26-09-2023
Publisher: Springer Science and Business Media LLC
Date: 2021
Publisher: Polish Society of Microbiologists
Date: 09-2022
Abstract: To explore the prevalence of multidrug-resistant community-associated uropathogenic Escherichia coli (UPEC) and their virulence factors in Western Saudi Arabia. A total of 1,000 urine s les were examined for the presence of E. coli by selective plating on MacConkey, CLED, and sheep blood agar. Antimicrobial susceptibility patterns were determined using Vitek ® 2 Compact (MIC) and the disc diffusion method with Mueller-Hinton agar. Genes encoding virulence factors ( kpsMTII , traT , sat , csgA , vat , and iutA ) were detected by PCR. The overall prevalence of UTI-associated E. coli was low, and a higher prevalence was detected in s les of female origin. Many of the isolates exhibited resistance to norfloxacin, and 60% of the isolates showed resistance to icillin. No resistance to imipenem, meropenem, or ertapenem was detected. In general, half of the isolates showed multiple resistance patterns. UPEC exhibited a weak ability to form biofilms, where no correlation was observed between multidrug resistance and biofilm-forming ability. All uropathogenic E. coli isolates carried the kpsMTII , iutA , traT , and csgA genes, whereas the low number of the isolates harbored the sat and vat genes. The ersity of virulence factors harbored by community-associated UPEC may render them more virulent and further explain the recurrence/relapse cases among community-associated UITs. To the best of our knowledge, this study constitutes the first exploration of virulence, biofilm-forming ability, and its association with multidrug resistance among UPEC isolates in Saudi Arabia. Further investigations are needed to elucidate the epidemiology of community-associated UPEC in Saudi Arabia.
Publisher: MDPI AG
Date: 26-11-2021
DOI: 10.3390/ANTIBIOTICS10121454
Abstract: Colistin is considered a last treatment option for multi-drug and extensively resistant Gram-negative infections. We aimed to assess the available data on the dosing strategy of colistin. A systematic review was performed to identify all published studies on the dose optimization of colistin. Grey literature and electronic databases were searched. Data were collected in a specified form and the quality of the included articles was then assessed using the Newcastle-Ottawa scale for cohort studies, the Cochrane bias tool for randomized clinical trials (RCT), and the Joanna Briggs Institute (JBI) critical checklist for case reports. A total of 19 studies were included, of which 16 were cohort studies, one was a RCT, and two were case reports. A total of 18 studies proposed a dosing regimen for adults, while only one study proposed a dosing schedule for pediatric populations. As per the available evidence, a loading dose of 9 million international units (MIU) of colistin followed by a maintenance dose of 4.5 MIU every 12 h was considered the most appropriate dosing strategy to optimize the safety and efficacy of treatment and improve clinical outcomes. This review supports the administration of a loading dose followed by a maintenance dose of colistin in severe and life-threatening multi-drug Gram-negative bacterial infections.
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End Date: End date not available
Funder: Umm Al-Qura University
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