ORCID Profile
0000-0003-2491-8169
Current Organisation
Murdoch University
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Publisher: American Chemical Society (ACS)
Date: 11-10-2019
Publisher: American Chemical Society (ACS)
Date: 07-07-2017
Publisher: American Chemical Society (ACS)
Date: 13-01-2015
DOI: 10.1021/EF5023237
Publisher: American Chemical Society (ACS)
Date: 23-03-2018
Publisher: American Chemical Society (ACS)
Date: 22-12-2017
Publisher: American Chemical Society (ACS)
Date: 17-12-2020
Publisher: American Chemical Society (ACS)
Date: 16-07-2014
DOI: 10.1021/EF501112Q
Publisher: American Chemical Society (ACS)
Date: 26-07-2021
Publisher: American Chemical Society (ACS)
Date: 17-08-2020
Publisher: American Chemical Society (ACS)
Date: 18-11-2019
Publisher: American Chemical Society (ACS)
Date: 09-2011
DOI: 10.1021/IE201092H
Publisher: Elsevier BV
Date: 07-2014
Publisher: Wiley
Date: 03-06-2019
DOI: 10.1002/KIN.21301
Publisher: American Chemical Society (ACS)
Date: 04-07-2021
Publisher: American Chemical Society (ACS)
Date: 29-11-2007
DOI: 10.1021/EF060420V
Publisher: Elsevier BV
Date: 10-2014
Publisher: American Chemical Society (ACS)
Date: 05-11-2013
DOI: 10.1021/EF401080X
Publisher: Elsevier BV
Date: 02-2016
Publisher: American Chemical Society (ACS)
Date: 16-04-2020
Publisher: Elsevier BV
Date: 07-2019
DOI: 10.1016/J.BRAINRESBULL.2019.04.006
Abstract: Although transplantation of bone marrow-derived mesenchymal stem cells (MSCs) has shown beneficial effects on stroke, lower survival of MSCs limits effects. Extracellular regulating kinase 1/2 signaling (ERK1/2) is crucial for cell survival, differentiation, and proliferation. This study was designed to explore whether MSCs modified by over-expressing ERK1/2 may reinforce beneficial effects on stroke in rats. rat MSCs transfected with ERK1/2 and empty lentivirus to generate MSCs overexpressing ERK1/2 (ERK/MSCs) and MSCs (as a control), respectively. In vitro, ERK/MSCs were plated and exposed to glutamate-induced condition, and viability of ERK/MSCs was measured. Furthermore, neural induction of ERK/MSCs was investigated in vitro. Cerebral ischemic rats were induced by occluding middle cerebral artery, and then were stereotaxically injected into ipsilateral right lateral ventricle with ERK/MSCs or MSCs 3 days after stroke and survived for 7 or 14 days after injection. ERK/MSCs showed better viability in physiological and glutamate-induced neurotoxic conditions compared to MSCs. After neural induction, more neurons were be differentiated from ERK/MSCs than from MSCs. After transplantation, more numbers of grafted cells and improved functional recovery were observed in ERK/MSCs-treated rats compared with MSCs-treated rats. Compared with MSCs treatment, ERK/MSCs treatment significantly increased proliferation of neural stem cells in the subventricle zone (SVZ) and the MAP2/nestin double-labeled cells adjacent to the SVZ, enhanced the numbers of reactive astrocytes while suppressed microglial activation. Besides, TNF-α level was elevated in ERK/MSCs-treated rats. ERK/MSCs transplantation showed better functional recovery after stroke in rats, likely in part through enhancing survival of MSCs and possibly by modulating the proliferation, neuronal de-differentiation and neuroinflammation.
Publisher: Elsevier BV
Date: 2015
Publisher: Elsevier BV
Date: 2017
Publisher: American Chemical Society (ACS)
Date: 09-12-2006
DOI: 10.1021/EF060324U
Publisher: American Chemical Society (ACS)
Date: 31-12-2013
DOI: 10.1021/EZ400165G
Publisher: American Chemical Society (ACS)
Date: 18-05-2011
DOI: 10.1021/EF200296U
Publisher: American Chemical Society (ACS)
Date: 17-10-2012
DOI: 10.1021/EF300211U
Publisher: American Chemical Society (ACS)
Date: 24-04-2017
Abstract: Dissolved organic matter (DOM) acts as an effective photochemical sensitizer that produces the singlet delta state of molecular oxygen (O
Publisher: Elsevier BV
Date: 2017
Publisher: Elsevier BV
Date: 2023
Publisher: American Chemical Society (ACS)
Date: 30-10-2018
Publisher: Elsevier BV
Date: 05-2016
Publisher: American Chemical Society (ACS)
Date: 12-02-2013
DOI: 10.1021/EF302148F
Publisher: American Chemical Society (ACS)
Date: 10-06-2019
Publisher: Elsevier BV
Date: 2021
Publisher: American Chemical Society (ACS)
Date: 05-08-2022
Publisher: American Chemical Society (ACS)
Date: 27-05-2022
Publisher: Elsevier BV
Date: 03-2018
Publisher: Springer Science and Business Media LLC
Date: 12-08-2019
DOI: 10.1038/S41557-019-0297-7
Abstract: Singlet fission-that is, the generation of two triplets from a lone singlet state-has recently resurfaced as a promising process for the generation of multiexcitons in organic systems. Although advances in this area have led to the discovery of modular classes of chromophores, controlling the fate of the multiexciton states has been a major challenge for ex le, promoting fast multiexciton generation while maintaining long triplet lifetimes. Unravelling the dynamical evolution of the spin- and energy conversion processes from the transition of singlet excitons to correlated triplet pairs and in idual triplet excitons is necessary to design materials that are optimized for translational technologies. Here, we engineer molecules featuring a discrete energy gradient that promotes the migration of strongly coupled triplet pairs to a spatially separated, weakly coupled state that readily dissociates into free triplets. This 'energy cleft' concept allows us to combine the lification and migration processes within a single molecule, with rapid dissociation of tightly bound triplet pairs into in idual triplets that exhibit lifetimes of ~20 µs.
Publisher: American Chemical Society (ACS)
Date: 21-12-2013
DOI: 10.1021/EF3018157
Publisher: American Chemical Society (ACS)
Date: 26-06-2014
DOI: 10.1021/EF501114V
Publisher: Elsevier BV
Date: 07-2017
Publisher: Elsevier BV
Date: 2023
Publisher: American Chemical Society (ACS)
Date: 06-10-2011
DOI: 10.1021/IE200679N
Publisher: Elsevier BV
Date: 2014
Publisher: Springer Science and Business Media LLC
Date: 05-2007
Publisher: American Chemical Society (ACS)
Date: 05-09-2013
DOI: 10.1021/SC4002406
Publisher: Elsevier BV
Date: 2019
Publisher: Elsevier BV
Date: 2015
Publisher: Elsevier BV
Date: 04-2019
Publisher: American Chemical Society (ACS)
Date: 05-08-2011
DOI: 10.1021/EF2008216
Publisher: American Chemical Society (ACS)
Date: 06-08-2015
Publisher: Elsevier BV
Date: 02-2022
Publisher: Elsevier BV
Date: 05-2016
Publisher: American Chemical Society (ACS)
Date: 02-2013
DOI: 10.1021/EF3020553
Publisher: American Chemical Society (ACS)
Date: 25-08-2016
Publisher: Elsevier BV
Date: 2017
Publisher: American Chemical Society (ACS)
Date: 26-05-2016
Publisher: American Chemical Society (ACS)
Date: 26-05-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8CP04852E
Abstract: Photo-degradation of organic pollutants plays an important role in their removal from the environment.
Publisher: American Chemical Society (ACS)
Date: 22-07-2016
Publisher: American Chemical Society (ACS)
Date: 28-07-2010
DOI: 10.1021/EF100701R
Publisher: Elsevier BV
Date: 08-2014
Publisher: American Chemical Society (ACS)
Date: 10-10-2013
DOI: 10.1021/EF401632H
Publisher: Elsevier BV
Date: 03-2018
No related grants have been discovered for Xiangpeng Gao.