ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0003-3281-5530

Current Organisations
Telethon Kids Institute , Murdoch University

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Research Topics

In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

Publications

Publication

Transplacental immune modulation with a bacterialderived agent protects against allergic airway inflammation

Publisher: American Society for Clinical Investigation

Date: 02-10-2018

DOI: 10.1172/JCI122631

Publication

Exacerbation of chronic cigarette-smoke induced lung disease by rhinovirus in mice

Publisher: Elsevier BV

Date: 04-2022

DOI: 10.1016/J.RESP.2022.103846

Abstract: A significant proportion of chronic obstructive pulmonary disease exacerbations are strongly associated with rhinovirus infection (HRV). In this study, we combined long-term cigarette smoke exposure with HRV infection in a mouse model. Our aim was to better understand the effects of HRV infection on such exacerbations, using a realistic method for generating a COPD-like phenotype. After 12-weeks of cigarette smoke exposure, adult female BALB/c mice were infected with HRV-1A and three days later we assessed a range of outcomes including lung volume and function, collected lung tissue for measurement of viral titre, bronchoalveolar lavage for assessment of pulmonary inflammation and levels of key mediators, and fixed lungs for stereological structural analyses. Cigarette smoke exposure alone significantly increased total cells and macrophages, and reduced MIP-2 in bronchoalveolar lavage. HRV-1A infection alone increased neutrophilic inflammation, IP-10 and total protein in lavage and also increased specific airway resistance measured at functional residual capacity. Cigarette smoke and HRV-1A together impacted various lung structural parameters including increasing stereological lung volume. Our results show that long-term cigarette smoke exposure and HRV-1A infection both in idually impact respiratory outcomes and combine to alter aspects of lung structure in a mouse model, thus providing insight into the development of future mechanistic studies and appropriate interventions in human disease.

Related Organisations

Organisation

Telethon Kids Institute

Location: Australia

View Organisation

Organisation

Murdoch University

Amount: $550,000.00

Funder: Australian Research Council

View Funded Activity

Phil Stumbles

Researcher

Research Topics

Top 5 Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

Publications

Transplacental immune modulation with a bacterialderived agent protects against allergic airway inflammation

Exacerbation of chronic cigarette-smoke induced lung disease by rhinovirus in mice

Related Organisations

Telethon Kids Institute

Murdoch University

Related Funding Activities

Linkage Projects - Grant ID: LP0776722

Linkage Projects - Grant ID: LP110100399

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100217

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989782

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100126

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100066

Discovery Projects - Grant ID: DP110101706

Phil Stumbles

Researcher

Research Topics

Top 5 Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

Related Links

Publications

Transplacental immune modulation with a bacterialderived agent protects against allergic airway inflammation

Exacerbation of chronic cigarette-smoke induced lung disease by rhinovirus in mice

Related Organisations

Telethon Kids Institute

Murdoch University

Related Funding Activities

Linkage Projects - Grant ID: LP0776722

Linkage Projects - Grant ID: LP110100399

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100217

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989782

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100126

Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100066

Discovery Projects - Grant ID: DP110101706

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