ORCID Profile
0000-0003-1631-0719
Current Organisations
Southern Cross University
,
Swinburne University of Technology
,
Deakin University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Springer Science and Business Media LLC
Date: 04-09-2020
DOI: 10.1186/S12711-020-00571-5
Abstract: Thousands of years of natural and artificial selection have resulted in indigenous cattle breeds that are well-adapted to the environmental challenges of their local habitat and thereby are considered as valuable genetic resources. Understanding the genetic background of such adaptation processes can help us design effective breeding objectives to preserve local breeds and improve commercial cattle. To identify regions under putative selection, GGP HD 150 K single nucleotide polymorphism (SNP) arrays were used to genotype 106 in iduals representing five Swedish breeds i.e. native to different regions and covering areas with a subarctic cold climate in the north and mountainous west, to those with a continental climate in the more densely populated south regions. Five statistics were incorporated within a framework, known as de-correlated composite of multiple signals (DCMS) to detect signatures of selection. The obtained p -values were adjusted for multiple testing (FDR 5%), and significant genomic regions were identified. Annotation of genes in these regions revealed various verified and novel candidate genes that are associated with a erse range of traits, including e.g. high altitude adaptation and response to hypoxia ( DCAF8 , PPP1R12A , SLC16A3 , UCP2 , UCP3 , TIGAR ), cold acclimation ( AQP3 , AQP7 , HSPB8 ), body size and stature ( PLAG1 , KCNA6 , NDUFA9 , AKAP3 , C5H12orf4 , RAD51AP1 , FGF6 , TIGAR , CCND2 , CSMD3 ), resistance to disease and bacterial infection ( CHI3L2 , GBP6 , PPFIBP1 , REP15 , CYP4F2 , TIGD2 , PYURF , SLC10A2 , FCHSD2 , ARHGEF17 , RELT , PRDM2 , KDM5B ), reproduction ( PPP1R12A , Z FP36L2 , CSPP1 ), milk yield and components ( NPC1L1 , NUDCD3 , ACSS1 , FCHSD2 ), growth and feed efficiency ( TMEM68 , TGS1 , LYN , XKR 4 , FOXA2 , GBP2 , GBP5 , FGD6 ), and polled phenotype ( URB1 , EVA1C ). We identified genomic regions that may provide background knowledge to understand the mechanisms that are involved in economic traits and adaptation to cold climate in cattle. Incorporating p -values of different statistics in a single DCMS framework may help select and prioritize candidate genes for further analyses.
Publisher: Australasian Association of Writing Programs
Date: 29-04-2021
DOI: 10.52086/001C.23488
Abstract: The scholars who present their work here in this Special Issue on Writing Through Things: Past and Broken Things were invited to contribute their research in the form of a traditional article or creative work that explores the fission between the arena of the mind and the concrete, tangible things of the world around us to explore that ‘unexplored world’ of ‘memory, emotion, and untapped creativity’ (Pollack, 2011: 230). The events of 2020, lockdowns and self-isolating, meant that we were, perhaps more than ever, surrounded by our own things, offering an opportunity to see these things differently and maybe more clearly. Bill Brown explains that “the work being done… under thing theory is addressing how it is that the inanimate object world helps to form and transform human beings. Part of that is to say: how does our material environment shape us?” (Brown, 2012). We, as writers and researchers, are concerned with that which forms and transforms us and the world around us. These catalysts of formation and transformation can be people, experiences, landscapes, and sometimes they can be the seemingly everyday objects that surround us. As Brown points out, the things that impact on us do not have to be those of ‘economic value in Marxist terms’ they can be ‘small things’ of ‘symbolic value’ (Brown, 2012).
Publisher: Copernicus GmbH
Date: 02-04-2019
Abstract: Abstract. This research aimed to measure the extent of linkage disequilibrium (LD), effective population size (Ne), and runs of homozygosity (ROHs) in one of the major Iranian sheep breeds (Zandi) using 96 s les genotyped with Illumina Ovine SNP50 BeadChip. The amount of LD (r2) for single-nucleotide polymorphism (SNP) pairs in short distances (10–20 kb) was 0.21±0.25 but rapidly decreased to 0.10±0.16 by increasing the distance between SNP pairs (40–60 kb). The Ne of Zandi sheep in past (approximately 3500 generations ago) and recent (five generations ago) populations was estimated to be 6475 and 122, respectively. The ROH-based inbreeding was 0.023. We found 558 ROH regions, of which 37 % were relatively long ( 10 Mb). Compared with the rate of LD reduction in other species (e.g., cattle and pigs), in Zandi, it was reduced more rapidly by increasing the distance between SNP pairs. According to the LD pattern and high genetic ersity of Zandi sheep, we need to use an SNP panel with a higher density than Illumina Ovine SNP50 BeadChip for genomic selection and genome-wide association studies in this breed.
No related grants have been discovered for Debra Wain.