ORCID Profile
0000-0003-2031-4288
Current Organisation
Deakin University
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Wiley
Date: 21-03-2017
DOI: 10.1111/ASWP.12119
Publisher: Informa UK Limited
Date: 03-2013
DOI: 10.1080/17457300.2011.648676
Abstract: Safety incentive and penalty (I/P) provisions in construction contracts are one of the most common forms of I/P. Contradictory opinions on the effectiveness of these provisions have been expressed in the literature. Statistics on safety provisions were collected from 32 construction projects, which include both types of contracts - those with safety I/P provisions and those without them. Although inclusion of safety I/P provisions in contracts helps in improving the overall safety performance in construction projects, further scope for improvement still exists. Literature review and structured personal interviews, coupled with a survey based on preliminary questionnaire, revealed that successful formulation and implementation of such provisions are dependent on 25 attributes which need the attention of both clients and contractors. A questionnaire-based survey was conducted to evaluate these attributes. The six factors extracted by carrying out factor analysis are: incentive distribution method, proper labour training, special attention to risky situations, role of safety committee and sub-contractors, specialised works and safety equipments, and right form of I/P. If taken care of, these attributes have the potential to improve the safety performance in construction projects. The results would be useful to clients and contractors in implementing the safety I/P provisions and thereby improving safety performance.
Publisher: Springer Science and Business Media LLC
Date: 29-08-2019
DOI: 10.1038/S41434-019-0097-0
Abstract: Differences between mouse and human hearts pose a significant limitation to the value of small animal models when predicting vector behavior following recombinant adeno-associated viral (rAAV) vector-mediated cardiac gene therapy. Hence, sheep have been adopted as a preclinical animal, as they better model the anatomy and cardiac physiological processes of humans. There is, however, no comprehensive data on the shedding profile of rAAV in sheep following intracoronary delivery, so as to understand biosafety risks in future preclinical and clinical applications. In this study, sheep received intracoronary delivery of rAAV serotypes 2/6 (2 × 10
Publisher: American Society of Civil Engineers (ASCE)
Date: 09-2022
Publisher: American Society of Civil Engineers (ASCE)
Date: 08-2016
Publisher: Springer Science and Business Media LLC
Date: 19-08-2014
Publisher: Emerald
Date: 11-02-2019
DOI: 10.1108/ECAM-06-2017-0104
Abstract: Delays in construction projects can be very expensive due to their adverse effects on project cost and profit margin. To overcome this problem, clients in the construction industry sometimes use schedule incentive/disincentive (I/D) contracting strategy. However, previous studies have shown that inadequate understanding and wrong implementation of schedule I/D provisions could result in unintended results. Moreover, the use of the I/D contracting method is in its initial stages in many countries such as India. The purpose of this paper is to identify various factors that are essential for schedule I/D success in construction projects. A questionnaire survey was conducted among experienced professionals (clients, contractors and consultants) from across the Indian construction industry. Top success factors related to clients in the descending order of their importance are: realistic targets detailed guidelines for I/D implementation close coordination with other stakeholders correct estimation of I/D duration and amount and imposing disincentives after due consideration. Meanwhile, factors related to contractor organisations are: continuous monitoring and control thorough understanding of schedule I/D targets specific considerations in appointing senior project personnel effective communication and proper labour management. This empirical research was conducted in the Indian construction industry. Similar studies from developed construction markets may provide more insights into the successful use of schedule I/D provisions in construction projects. The uptake of these recommendations is likely to increase the success of schedule I/D provisions in construction projects, especially in developing countries where the use of I/D contracting strategy is not very popular. This research highlights the specific roles of both clients and contractors in the success of schedule I/D projects in developing countries such as India.
Publisher: Informa UK Limited
Date: 19-05-2019
Publisher: Elsevier BV
Date: 08-2016
DOI: 10.1016/J.HLC.2016.04.011
Abstract: Atrial Fibrillation (AF) is one of the most common types of cardiac arrhythmias experienced in clinical practice, increasing the risk of stroke, dementia, myocardial infarction and death. Currently available options for the treatment of AF use either pharmacological agents or catheter-based ablation therapies to restore sinus rhythm or control the ventricular response rate. These current treatment options are suboptimal at best, motivating research into discovering more effective and innovative ways to treat AF. Gene therapy is being explored for its potential to treat various human conditions including cardiac arrhythmias. Gene transfer vectors with increasing transduction efficiency and biosafety have been developed and trialled for cardiovascular disease treatment. With an improved understanding of the molecular mechanisms of AF, several gene therapy targets have been identified and evaluated in an attempt to rate or rhythm control the heart during AF. This review will discuss the gene therapy vectors in use today and methods for delivery of these vectors to the atrium. Further, it will evaluate several gene therapy strategies and approaches for sinus rhythm restoration and ventricular rate control that have the potential to emerge as a therapy for AF.
Publisher: Emerald
Date: 14-10-2021
DOI: 10.1108/ECAM-10-2020-0854
Abstract: Although the adverse effects of construction activities on the environment and the need for sustainable construction practices are recognised in both research and practice, any significant shift in the selection and use of construction materials from the sustainability perspective has not taken place in many building projects. Still, conventional construction materials are widely used in building projects in both developed and developing countries. This study attempts to identify the main barriers to the use of sustainable materials in building projects in an advanced economy such as Australia. This study adopted a questionnaire survey approach to examine the main reasons behind the low usage of sustainable materials in building projects. Based on the relative importance index, exploratory factor analysis and multinomial logistic regression analysis, the study examined the main barrier measures and barrier factors to the use of sustainable materials in building projects. The findings reveal that critical barriers to the use of sustainable materials are related to cost and profit considerations, the unwillingness of the key stakeholders to incorporate these materials into building projects, lack of incentives and government policies. The factor analysis reduced the critical barrier measures into three factors: techno-economic considerations, cost and delay concerns and resistance to use. Furthermore, multinomial regression analysis based on the extracted factors identified techno-economic considerations as the main barrier factor to the use of sustainable materials in building projects. The empirical results of this research can inform construction practitioners, organisations and policymakers on how to increase the use of sustainable building materials in the construction industry. Identification of barriers to the use of sustainable building materials is a prerequisite to improve their uptake and use in the construction industry. The study fills a gap in the existing research on the use of sustainable materials in building projects in Australia.
Publisher: American Society of Civil Engineers (ASCE)
Date: 09-2022
Publisher: Elsevier BV
Date: 11-2014
Publisher: Springer Science and Business Media LLC
Date: 20-07-2020
Publisher: Emerald
Date: 13-12-2022
DOI: 10.1108/ECAM-11-2021-1022
Abstract: Data from different countries suggest a higher prevalence of anxiety, depression and suicides among manual and trade workers in the construction industry than in the general population. The present review examines the causes and effects of poor mental health and the effectiveness of interventions to improve manual and trade workers' mental health in the construction industry. It also identifies gaps in research and makes several suggestions for practice and future research. A systematic literature review was conducted to examine and consolidate evidence reported in 54 relevant journal articles published between 2010 and 2021 on the mental health of manual and trade workers. Three major themes emerged in the review of the 54 journal articles: causes of poor mental health, effects of poor mental health and interventions to improve mental health. The leading causes of poor mental health among construction manual and trade workers are poor work-life balance, high job demand, poor cultural norms and mental health stigma, chronic bodily pain, lack of social support, workplace injustice and job insecurity. The prominent effects of poor mental health are suicidality, drug and alcohol addiction, poor workplace safety and poor work performance. Moreover, the study found that some of the strategies recently implemented in the construction industry to improve mental health are deemed ineffective, or their effectiveness remains inconclusive. The review's scope is limited to research on manual and trade workers, and it did not investigate the mental health of construction professionals and construction management students. The review provides valuable insights into the causes and effects of poor mental health among manual and trade workers and the effectiveness of mental health interventions in the construction industry.
Publisher: Elsevier BV
Date: 11-2015
Publisher: Elsevier BV
Date: 04-2017
DOI: 10.1016/J.HLC.2016.11.002
Abstract: Numerous pharmacological and device therapies have improved adverse cardiac remodelling and mortality in heart failure. However, none are able to regenerate damaged cardiac tissue. Stem cell based therapies using multipotent (adult) stem cells and pluripotent stem cells are new approaches that could potentially achieve the elusive goal of true cardiac regeneration. Over the past two decades, various stem cell based approaches have been shown to improve left ventricular function in pre-clinical animal models. Promising results rapidly led to clinical trials, initially using bone marrow-derived mononuclear cells, then mesenchymal stromal cell populations and, more recently, progenitor cells from the adult heart itself. These have been shown to be safe and have advanced our understanding of potential suitable recipients, cell delivery routes, and possible mechanisms of action. However, efficacy in these trials has been inconsistent. Human pluripotent stem cells (hPSCs) are another potential source of stem cells for cardiac regeneration. They could theoretically provide an unlimited source of cardiomyocytes or cardiac progenitors. Pre-clinical studies in both small and large animal models have shown robust engraftment and improvements in cardiac function. The first clinical trial using hPSC-derived cardiac derivatives has now commenced and others are imminent. In this brief review article, we summarise recent developments in stem cell therapies aimed at cardiac regeneration, including discussion of types of cell and non-cell-based strategies being explored.
Publisher: Elsevier BV
Date: 10-2020
Publisher: Emerald
Date: 08-11-2022
DOI: 10.1108/JEDT-11-2021-0657
Abstract: The Afghan construction industry faces resource shortages and heavily relies on foreign aid to fund public projects on the path to recovery and reconstruction. While the resource constraints demand cost-efficient delivery of construction projects, many Afghan public projects experience delays and cost overruns. This study aims to evaluate various attributes and factors influencing cost performance in public construction projects in Afghanistan. The literature review and Delphi method identified 30 cost performance attributes relevant to the context of Afghanistan. Next, a questionnaire survey was conducted with construction management professionals working in the public sector in the Afghan construction industry to evaluate these attributes. This study found that the lack of resources, poor project management skills and corruption in procurement are the leading causes behind cost overruns in Afghan public projects. This study also identified five latent factors influencing cost performance in public projects in Afghanistan: competency of the project team, socioeconomic and political support, governance and public procurement, planning and risk management and project characteristics. The exploratory factor analysis did not reveal the relative significance of different cost performance success factors. Moreover, the ranking of cost performance attributes is based on the responses from the public sector construction professionals only. The construction industry in Afghanistan significantly contributes to the country’s social and economic growth and employment. This study’s findings will help researchers, project sponsors, government departments and industry practitioners interested in improving the cost performance in Afghan public projects. Given the scarcity of research in war-affected and conflict-sensitive regions, this study fills a research gap on project cost performance by providing insights into the cost performance success factors in public projects in Afghanistan.
Publisher: Mary Ann Liebert Inc
Date: 07-2013
Publisher: Informa UK Limited
Date: 02-03-2023
Publisher: Elsevier BV
Date: 09-2012
DOI: 10.1016/J.HLC.2012.04.020
Abstract: Cell therapies specifically targeting heart failure could greatly decrease morbidity and burgeoning health care costs worldwide. Due to the great number of cell types being investigated, navigating the cardiovascular regeneration field can be difficult. This brief review gives an overview of the main cell types being explored for cardiac cell therapy. These include populations from extra-cardiac sources (skeletal myoblasts, bone marrow derived mononuclear cells, endothelial progenitor cells, bone marrow or adipose derived mesenchymal stem cells and embryonic or induced pluripotent stem cells as well as newly discovered cardiac stem cell populations (isl1(+), c-kit(+), sca1(+), sca1(+) dgfrα(+), cardiosphere derived, cardiac side-population and epicardium derived cells). Although clinical trials using both groups of cell sources have been performed, the vast majority of studies have used bone marrow mononuclear cells. The current wave of clinical trials includes large studies refining specifics of bone marrow mononuclear cell therapy and early phase trials of mesenchymal stem cell and cardiac stem cell populations. Embryonic stem cell derived therapies are being studied in large animal models with the aim of swift progression to clinical trials. Lessons learnt from the intense investigation in this infant field have resulted in rapid translational progress and it is likely that several clinical products rotocols for cardiac repair will be available in the not too distant future.
Publisher: Springer International Publishing
Date: 04-10-2019
Publisher: Springer Science and Business Media LLC
Date: 18-07-2016
DOI: 10.1038/CDDISCOVERY.2016.52
Abstract: Stem cell therapy is being investigated as an innovative and promising strategy to restore cardiac function in patients with heart failure. Several stem cell populations, including adult (multipotent) stem cells from developed organs and tissues, have been tested for cardiac repair with encouraging clinical and pre-clinical results. The heart has been traditionally considered a post-mitotic organ, however, this view has recently changed with the identification of stem rogenitor cells residing within the adult heart. Given their cardiac developmental origins, these endogenous cardiac progenitor cells (CPCs) may represent better candidates for cardiac cell therapy compared with stem cells from other organs such as the bone marrow and adipose tissue. This brief review will outline current research into CPC populations and their cardiac repair/regenerative potential.
Publisher: Elsevier BV
Date: 11-2014
DOI: 10.1016/J.SCR.2014.09.008
Abstract: Mammalian hearts carry a number of primitive stem cell-like populations, although the magnitude of their contribution to tissue homeostasis and repair remains controversial. Recent CRE recombinase-based lineage tracing experiments suggest only a minor contribution to the formation of new cardiomyocytes from such cells, albeit one that might be augmented therapeutically. As the field explores clinical translation of cardiac stem cells, it will be important to understand the biology of these cells in great detail. In this review we document the various reported stem and progenitor cell populations in mammalian hearts and discuss the current state of knowledge on their origins and lineage capabilities.
Publisher: Springer Science and Business Media LLC
Date: 05-09-2022
DOI: 10.1038/S41467-022-32946-1
Abstract: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare yet serious adverse effect of the adenoviral vector vaccines ChAdOx1 nCoV-19 (AstraZeneca) and Ad26.COV2.S (Janssen) against COVID-19. The mechanisms involved in clot formation and thrombocytopenia in VITT are yet to be fully determined. Here we show neutrophils undergoing NETosis and confirm expression markers of NETs in VITT patients. VITT antibodies directly stimulate neutrophils to release NETs and induce thrombus formation containing abundant platelets, neutrophils, fibrin, extracellular DNA and citrullinated histone H3 in a flow microfluidics system and in vivo. Inhibition of NETosis prevents VITT-induced thrombosis in mice but not thrombocytopenia. In contrast, in vivo blockage of FcγRIIa abrogates both thrombosis and thrombocytopenia suggesting these are distinct processes. Our findings indicate that anti-PF4 antibodies activate blood cells via FcγRIIa and are responsible for thrombosis and thrombocytopenia in VITT. Future development of NETosis and FcγRIIa inhibitors are needed to treat VITT and similar immune thrombotic thrombocytopenia conditions more effectively, leading to better patient outcomes.
Publisher: American Society of Civil Engineers (ASCE)
Date: 11-2018
Publisher: American Society of Civil Engineers (ASCE)
Date: 02-2016
Publisher: American Society of Civil Engineers (ASCE)
Date: 09-2021
Publisher: American Society of Civil Engineers (ASCE)
Date: 08-2020
Publisher: American Society of Civil Engineers (ASCE)
Date: 10-2022
Publisher: Springer Science and Business Media LLC
Date: 03-12-2015
Publisher: American Society of Civil Engineers (ASCE)
Date: 02-2023
Publisher: Emerald
Date: 29-05-2018
DOI: 10.1108/BEPAM-10-2017-0080
Abstract: The issue of low productivity has remained a very stern and chronic problem in construction projects. Previous studies have found poor communication as one of the leading causes of low-construction productivity. Recent advances in the field of information and communication technologies (ICT) have the potential to enhance communication and access to information in construction projects. However, the implications of the use of mobile ICT on construction productivity have not been investigated in sufficient depth, especially from the perspectives of its users, i.e. construction management (CM) professionals. The paper aims to discuss these issues. A focus group session involving ten experienced CM professionals from different organisations of the South Australian construction industry was moderated by a group of four researchers to gather data on mobile ICT usage and its implications for construction productivity. Lack of training and guidelines on effective applications of these technologies to construction projects is a major bottleneck. Results indicate that despite noticeable advances in mobile ICT, differences in usage style and user attitude have limited their overall impact on productivity. This paper is based on data gathered from CM professionals working in the South Australian construction industry. The study highlights the importance of strategising the use of mobile ICT to achieve the desired productivity rates through policy, training, work-life balance, and deeper and wider understanding of these technologies. The study examines the perceptions of CM professionals on the usefulness of mobile ICT in construction projects and its implications for construction productivity.
Publisher: American Society of Civil Engineers (ASCE)
Date: 07-2021
Publisher: Springer Science and Business Media LLC
Date: 30-04-2014
DOI: 10.1038/NATURE13233
Publisher: Springer International Publishing
Date: 06-11-2021
Publisher: Emerald
Date: 08-2018
DOI: 10.1108/ECAM-02-2017-0035
Abstract: A significant amount of work has been performed in the area of identification of factors affecting construction productivity. Previous studies have tried to determine the most important factors affecting construction productivity in different countries for a long time. As a result of continuous effort in this direction, researchers have identified a wide range of factors. While the subject area has matured, no general agreement could be made on the factors affecting construction productivity. To fill this gap, the purpose of this paper is to undertake a comprehensive systematic review of mainstream studies on factors affecting construction productivity published in the last 30 years (1986–2016). A total of 46 articles from different sources such as journals, conference proceedings, dissertation and PhD theses were identified and thoroughly reviewed. Gaps in research and practices are discussed and directions for future research have been proposed. The literature review indicates that despite noticeable differences in the socio-economic conditions across both developed countries and developing countries, an overall reasonable consensus exists on few significant factors impeding productivity. These are, namely, non-availability of materials, inadequate supervision, skill shortage, lack of proper tools and equipment and incomplete drawing and specifications. Nevertheless, implications of technology, site amenities, process studies, project culture, and impacts of physiological and psychological factors were not adequately covered in existing literature. The study also found that traditional construction projects have remained the main focus of these studies while green construction projects have been generally overlooked. The review does not include studies that report productivity at the organisational or industry level as well as total factor productivity. The scope of the review is limited to work on identification of factors affecting productivity at the activity level in construction projects. The outcomes of this study would help researchers and practitioners by providing the findings of previous studies in a concise manner. It is also expected that presenting a deeper and wider perspective of the research work performed until now will direct a more focussed approach on productivity improvement efforts in the construction industry. This review paper undertakes a comprehensive systematic review of studies on identification of factors affecting construction productivity published during the last three decades.
Publisher: Oxford University Press (OUP)
Date: 11-2006
DOI: 10.1016/J.EUJE.2006.09.001
Abstract: Melanoma is the most common form of cardiac metastases. Surgical excision has been shown to be an effective palliative measure. This requires detailed definition of cardiac anatomy in relation to the tumour. Two-dimensional (2D), three-dimensional (3D) transthoracic (TTE) and transoesophageal echocardiography (TEE), spiral computerised tomography (CT) and magnetic resonance imaging (MRI) have all been described in aiding surgical planning for excision of cardiac tumours. In this case report, 3D-TTE provided excellent anatomical definition for surgical planning of a large right atrial melanoma precluding the need for more invasive and expensive investigations.
Publisher: Elsevier BV
Date: 2008
DOI: 10.1016/J.AMJCARD.2007.08.051
Abstract: Electrophysiologic studies predict the risk for sudden death after myocardial infarction (MI). Although primary angioplasty has become the preferred method of treatment for ST-elevation MI, intravenous thrombolysis remains the first-line treatment in 30% to 70% of cases worldwide. Rates of ventricular tachyarrhythmias may vary according to type of reperfusion treatment. This study was undertaken to examine the hypothesis that the left ventricular ejection fraction (LVEF) and rates of inducible ventricular tachycardia may be more favorable in treatment with primary angioplasty rather than thrombolysis. Consecutive patients receiving primary angioplasty (n = 225) or thrombolysis (n = 195) for ST-elevation MI were included. The mean LVEF was 48 +/- 12% for the primary angioplasty group and 46 +/- 13% for the thrombolysis group (p = 0.30). The proportion of patients with LVEFs <40% was 30% in the primary angioplasty group and 30% in the thrombolysis group (p = 0.98). Patients with LVEFs <40% underwent electrophysiologic studies. Ventricular tachycardia was inducible in 23 of 66 primary angioplasty patients (34.8%) compared with 21 of 55 (38.1%) thrombolysis patients (p = 0.69). Implantable cardiac defibrillators were inserted in 30 patients, of whom 8 (27%) had appropriate device activations. The mean time from MI to first spontaneous activation was 387 +/- 458 days. In conclusion, patients treated with thrombolysis or primary angioplasty for ST-elevation MIs had similar resultant LVEFs and rates of inducible ventricular tachycardia. There was a surprisingly high rate of spontaneous defibrillator activations, often occurring late after MI.
Publisher: Emerald
Date: 11-07-2022
DOI: 10.1108/ECAM-01-2022-0059
Abstract: The poor quality of construction work in war-affected regions is a significant issue. The large-scale destruction to the existing infrastructure from the war necessitates cost and time-efficient delivery of construction projects during and post-war to bring normalcy to affected lives and places. Consequently, there is always a tendency to finish construction projects in the shortest possible time on a limited budget without following the proper quality management processes. However, the poor quality of construction projects continues to affect the country's development, growth, credibility, reputation, and public safety for several years after the war. To this end, the present study was conducted to evaluate the significant attributes and factors contributing to the poor quality of construction projects in the war-affected Afghan construction sector. A total of 31 attributes influencing construction project quality were ranked based on 110 completed survey responses collected from Afghan construction professionals. Moreover, independent s les t -test, Spearman's rank correlation test, and exploratory factor analysis were conducted. The study found a moderate consensus between clients and contractors on attributes' rankings. In addition, the independent s les t -test showed statistically significant differences in means values of responses from clients and contractors for eight attributes. Based on factor analysis, 19 important attributes (median value greater than or equal to four) were classified into 4 latent factors – (1) poor-quality assurance and control, (2) unethical practices, (3) design and drawing errors, and (4) knowledge and skills gap. Evaluating the factors affecting the quality of construction projects will help clients, government departments, and construction practitioners improve the construction quality management practices. The findings will also inform the policies and procedures of international aid providers.
Publisher: Emerald
Date: 20-12-2021
DOI: 10.1108/ECAM-05-2019-0277
Abstract: While mobile Information and Communication Technologies (mobile ICTs) have been adopted by many construction organisations, research on the usage of mobile technologies in the context of construction project management has been scarce. Against this background, the purpose of this paper is to enhance the understanding of how Construction Management Professionals (CMPs) currently use mobile ICTs at work and the factors affecting their usage of mobile ICTs in the context of the Australian construction industry. In this research, the aim is addressed by a survey-based empirical research approach. A questionnaire was used to collect data about CMPs’ current mobile ICT usage and the factors affecting the usage. Then, relative importance index, factor analysis and χ 2 test were used to identify the most significant factors affecting their mobile ICT usage. This research found that user characteristics such as age or years of experience are not the major factors affecting CMPs’ mobile ICT usage. The research also found that there are several barriers hindering an effective usage of mobile ICTs, namely work-family spillover, system quality issues, inconsistency in the way of using mobile ICTs among CMPs and the lack of organisational support. The results of this research imply that to fully reap the potential benefits of mobile ICTs in construction projects, those barriers need to be addressed appropriately at the in idual, organisational and industry levels. Also, this research informs construction organisations of how mobile ICTs can be deployed and used in the most cost-effective way in their projects.
Publisher: Springer International Publishing
Date: 04-10-2019
Publisher: American Society of Civil Engineers (ASCE)
Date: 03-2023
Publisher: Emerald
Date: 14-06-2021
DOI: 10.1108/ECAM-03-2021-0257
Abstract: The construction industry has a poor reputation for an unhealthy lifestyle and a high prevalence of health problems such as obesity, stress and hypertension among construction workers. The review examines the factors influencing the design and delivery of health promotion programs implemented by construction organisations to educate workers and promote a healthy lifestyle. It also identifies gaps in research and practices and proposes directions for future research. A systematic review of 51 relevant journal articles published during 2010–2019 was undertaken to achieve the aim of the study. The review reveals 46 different factors grouped into four major themes related to in iduals, organisations, industry and the program, influencing the successful implementation of health promotion programs. The top ten most cited factors are cost, time, facilities and resources, transient workforce, delivery method, influence from managers, long working hours, masculine culture, production pressure and interest. The review also found a noticeable lack of studies on implementing health promotion programs in the context of developing countries, small and medium-sized construction organisations, residential sector workers, and construction professionals and female workers. The review's scope is limited to research on health promotion programs, and it did not investigate the factors affecting the health of construction workers in construction projects. A better understanding of various influencing factors present at different decision levels will inform the future implementation of targeted workforce health promotion strategies to foster construction workers' health and well-being. The review reveals bottlenecks that need to be addressed to successfully implement health promotion programs in the construction industry. It provides new insights that can improve existing health and workplace policies and health promotion programs in the construction industry. Finally, it identifies new research directions in a neglected but crucial area of workers' health and safety management.
Publisher: American Society of Civil Engineers
Date: 13-12-2018
Publisher: American Society of Civil Engineers (ASCE)
Date: 05-2022
Publisher: Elsevier BV
Date: 2020
Publisher: American Society of Civil Engineers (ASCE)
Date: 09-2022
Publisher: American Society of Civil Engineers (ASCE)
Date: 05-2021
Publisher: American Society of Civil Engineers (ASCE)
Date: 11-2019
Publisher: MDPI AG
Date: 19-10-2018
DOI: 10.3390/JCDD5040050
Abstract: Bradycardia arising from pacemaker dysfunction can be debilitating and life threatening. Electronic pacemakers serve as effective treatment options for pacemaker dysfunction. They however present their own limitations and complications. This has motivated research into discovering more effective and innovative ways to treat pacemaker dysfunction. Gene therapy is being explored for its potential to treat various cardiac conditions including cardiac arrhythmias. Gene transfer vectors with increasing transduction efficiency and biosafety have been developed and trialed for cardiovascular disease treatment. With an improved understanding of the molecular mechanisms driving pacemaker development, several gene therapy targets have been identified to generate the phenotypic changes required to correct pacemaker dysfunction. This review will discuss the gene therapy vectors in use today along with methods for their delivery. Furthermore, it will evaluate several gene therapy strategies attempting to restore biological pacing, having the potential to emerge as viable therapies for pacemaker dysfunction.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 24-10-2014
No related grants have been discovered for Abid Hasan.