ORCID Profile
0000-0002-0118-3094
Current Organisations
Murdoch University
,
CY O'Connor ERADE Village Foundation
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Publisher: IntechOpen
Date: 02-10-2019
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 06-2018
Publisher: IOP Publishing
Date: 07-1998
Publisher: IOP Publishing
Date: 13-05-2003
Publisher: Hindawi Limited
Date: 2017
DOI: 10.1155/2017/3948408
Abstract: Extreme marbling or intramuscular deposition of lipid is associated with Wagyu breeds and is therefore assumed to be largely inherited. However, even within 100% full blood Wagyu prepared under standard conditions, there is unpredictable scatter of the degree of marbling. Here, we evaluate melting temperature ( T m ) of intramuscular fat as an alternative to visual scores of marbling. We show that “long fed” Wagyu generally has T m below body temperature but with a considerable range under standardized conditions. In idual sires have a major impact indicating that the variation is genetic rather than environmental or random error. In order to measure differences of lower marbling breeds and at shorter feeding periods, we have compared T m in subcutaneous fat s les from over the striploin. Supplementary feeding for 100 to 150 days leads to a rapid decrease in T m of 50% Red Wagyu (Akaushi) : 50% European crosses, when compared to 100% European. This improvement indicates that the genetic effect of Wagyu is useful, predictable, and highly penetrant. Contemporaneous DNA extraction does not affect the measurement of T m . Thus, provenance can be traced and substitution can be eliminated in a simple and cost-effective manner.
Publisher: Wiley
Date: 23-03-2015
Abstract: Soma-to-germline feedback is forbidden under the neo-Darwinian paradigm. Nevertheless, there is a growing realization it occurs frequently in immunoglobulin (Ig) variable (V) region genes. This is a surprising development. It arises from a most unlikely source in light of the exposure of co-author EJS to the haplotype data of RL Dawkins and others on the polymorphism of the Major Histocompatibility Complex, which is generally assumed to be the most polymorphic region in the genome (spanning ∼4 Mb). The comparison between the magnitude of MHC polymorphism with estimates for the human heavy chain immunoglobulin V locus (spanning ∼1 Mb), suggests IGHV could be many orders of magnitude more polymorphic than the MHC. This conclusion needs airing in the literature as it implies generational churn and soma-to-germline gene feedback. Pedigree-based experimental strategies to resolve the IGHV issue are outlined.
Publisher: Hindawi Limited
Date: 2017
DOI: 10.1155/2017/6532837
Abstract: Traditional analyses of a QTL on Bota 19 implicate a surfeit of candidates, but each is of marginal significance in explaining the deposition of healthy, low melting temperature fat within marbled muscle of Wagyu cattle. As an alternative approach, we have used genomic, multigenerational segregation to identify 14 conserved, ancestral 20 Mb haplotypes. These determine the degree and rate of marbling in Wagyu and other breeds of cattle. The melting temperature of intramuscular fat is highly heritable and traceable by haplotyping. Fortunately, for the production of healthy beef, some of these haplotypes are sufficiently penetrant to be expressed in heterozygous crossbreds, thereby allowing selection of sires which will improve the healthiness of beef produced under even harsh climatic conditions. The region of Bota 19 is syntenic to a region of Hosa 17 known to be important in muscle metabolism and in determining susceptibility to a form of human muscular dystrophy.
No related grants have been discovered for Sally Lloyd.