ORCID Profile
0000-0001-9960-0038
Current Organisations
Woods Hole Oceanographic Institution
,
University of Tasmania
,
The University of Maine
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Marine Geoscience | Palaeoclimatology | Simulation And Modelling | Geology | Data Structures | Seismology and Seismic Exploration | Interorganisational Information Systems | Geophysics | Artificial Intelligence and Image Processing | Earth Sciences Not Elsewhere Classified | Information Systems | Ocean Engineering | Natural Resource Management
Expanding Knowledge in the Earth Sciences | Effects of Climate Change and Variability on Australia (excl. Social Impacts) | Information processing services | Oil and Gas Exploration | Mineral Resources (excl. Energy Resources) not elsewhere classified | Navy | Application packages | Natural Hazards in Antarctic and Sub-Antarctic Environments | Oil and gas |
Publisher: Geological Society of America
Date: 2007
DOI: 10.1130/G23741A.1
Publisher: Elsevier BV
Date: 2018
Publisher: Springer Netherlands
Date: 2016
Publisher: American Geophysical Union (AGU)
Date: 29-11-1994
DOI: 10.1029/94EO02037
Publisher: Geological Society of America
Date: 2003
DOI: 10.1130/G19441.1
Publisher: American Geophysical Union (AGU)
Date: 12-1998
DOI: 10.1029/98PA02357
Publisher: Springer Netherlands
Date: 2016
Publisher: American Geophysical Union (AGU)
Date: 11-02-1992
DOI: 10.1029/91EO00059
Publisher: American Geophysical Union (AGU)
Date: 14-11-1995
DOI: 10.1029/95EO00292
Publisher: American Association for the Advancement of Science (AAAS)
Date: 04-1983
DOI: 10.1126/SCIENCE.220.4592.67
Abstract: Identification of a sequence of east-west trending magnetic anomalies of Mesozoic age in the western Somali Basin helps define the position of Madagascar in the Gondwana reconstruction. The anomalies are symmetric about ancient ridge segments and are flanked to the north and south by the Jurassic magnetic quiet zone. The motion of Madagascar relative to Africa was from the north and began in the middle Jurassic, about the same time as the initial breakup of Gondwanaland. Sea-floor spreading ceased when Madagascar assumed its present position in the Early Cretaceous.
Publisher: Springer Science and Business Media LLC
Date: 11-2019
DOI: 10.1038/S41523-019-0127-5
Abstract: Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1 , BRCA2 , PALB2 , ATM , and CHEK2 are associated with breast cancer risk. FANCM , which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM :p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2 . These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM −/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM :p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79 P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM :p.Arg658* and found that also FANCM :p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96 P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM :p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM -associated tumors.
Publisher: Elsevier BV
Date: 10-2017
Publisher: American Geophysical Union
Date: 18-03-1997
DOI: 10.1029/GM100P0411
Publisher: American Geophysical Union (AGU)
Date: 22-02-2011
DOI: 10.1029/2011EO080002
Publisher: Geological Society of America
Date: 2005
DOI: 10.1130/B25469.1
Publisher: Geological Society of America
Date: 2005
DOI: 10.1130/G21142.1
Publisher: Geological Society of America
Date: 2007
DOI: 10.1130/G24882Y.1
Publisher: OTC
Date: 03-05-1982
DOI: 10.4043/4259-MS
Abstract: R/V VEMA cruise 3618 multi-channel seismic line 84 combined with DSDP Site 241 drilling results documents important events in the sedimentary history of the southeastern Somaliland-northeastern Kenyan continental margin. Prominent diapers of presumed evaporate origin appear near the landward end of the profile. These evaporates were deposited in Early to Middle Jurassic time during the rift and early drift stages of the separation between Madagascar and Africa. A zone of chaotic reflectors, primarily confined to the Upper Cretaceous/Paleocene section, occurs down slope and seaward of the diapers and terminates abruptly. This zone is interpreted to be a massive sediment slide, whose seismic reflection character results from intense deformation. The slide may have been initiated by halo kinesis upslope and/or earthquake activity associated with the East African rifting. Beneath the lower continental rise seaward of the gravity slide is a large buried channel of Miocene age. This channel is likely the result of rapid sea level fluctuations and turbidity current activity initiated by East African rifting. A strong reflector is observed at ? 8 s depth near the seaward edge of the sediment slide. This reflector, which continues to the seaward end of the line and immediately overlies basement is thought to represent lime stones of Middle to Late Jurassic age. From November, 1980 through January, 1981, R/V VEMA cruises 3618 and 3619 were devoted to studying the East African continental margin and evolution of the western Somali Basin. Multi- and single-channel seismic reflection, son buoy reflection/refraction, gravity, magnetic and echo sounding measurements were recorded during these cruises. We will show here prominent features that we observe on one of the multi-channel seismic lines (line 84, location in Fig. 1) that demonstrate important processes affecting the passive continental margin of southeastern Somalia and northeastern Kenya. These features include diapers, a sediment slide and a deep-sea channel system (see Fig. 2). We are able to constrain the ages of the above processes by seismic correlation with a deep sea drill hole (DSDP hole 241, Leg 25)1. The VEMA multi-channel data were recorded at 4 ms intervals by a Texas Instruments DFS IV digital acquisition system from a 1200 m long 12-channel Seismic Engineering streamer. Two synchronized Bolt Associates 466-cu. in. air guns, fired at 15 to 20 second intervals, provided the sound source. SSQ 41, 42, and 57 son buoys were deployed frequently along the lines to obtain velocity information. Completed processing of line 84 off East Africa includes demultiplexing, common-depth-point gather, l2-channel velocity analysis, normal move-out correction, 12-fold stacking, band-pass filtering, time variable gain, disconsolation before and after stacking and, in places, wave-equation migration 2 Velocity analyses were performed using the semblance technique of Tanner and Koehler3 Input velocities for the move-out correction were also based on son buoy refraction information, especially for the deeper 1ayers. Deep Sea Drilling Project Site 241, drilled in a water depth of 4054 meters, is located on the continental rise off northeastern Kenya-southeastern Somalia1
Publisher: American Geophysical Union (AGU)
Date: 21-11-2006
DOI: 10.1029/2006EO470006
Publisher: Elsevier BV
Date: 2004
Publisher: American Geophysical Union (AGU)
Date: 10-08-2001
DOI: 10.1029/2001JB000370
Publisher: Elsevier BV
Date: 04-2011
Publisher: Elsevier BV
Date: 02-1988
Publisher: Geological Society of America
Date: 2004
DOI: 10.1130/G20319.1
Publisher: American Geophysical Union (AGU)
Date: 12-2003
DOI: 10.1029/2002GC000498
Publisher: American Geophysical Union (AGU)
Date: 16-07-2013
DOI: 10.1002/2013EO290008
Publisher: American Geophysical Union (AGU)
Date: 03-2020
DOI: 10.1029/2019EA000695
Abstract: Bubble emission mechanisms from submerged large igneous provinces remains enigmatic. The Kerguelen Plateau, a large igneous province in the southern Indian Ocean, has a long sustained history of active volcanism and glacial/interglacial cycles of sedimentation, both of which may cause seafloor bubble production. We present the results of hydroacoustic flare observations around the underexplored volcanically active Heard Island and McDonald Islands on the Central Kerguelen Plateau. Flares were observed with a split‐beam echosounder and characterized using multifrequency decibel differencing. Deep‐tow camera footage, water properties, water column δ 3 He, subbottom profile, and sediment δ 13 C and δ 34 S data were analyzed to consider flare mechanisms. Excess δ 3 He near McDonald Islands seeps, indicating mantle‐derived input, suggests proximal hydrothermal activity McDonald Islands flares may thus indicate CO 2 , methane, and other minor gas bubbles associated with shallow diffuse hydrothermal venting. The Heard Island seep environment, with subbottom acoustic blanking in thick sediment, muted 3 He signal, and δ 13 C and δ 34 S fractionation factors, suggest that Heard Island seeps may either be methane gas (possibly both shallow biogenic methane and deeper‐sourced thermogenic methane related to geothermal heat from onshore volcanism) or a combination of methane and CO 2 , such as seen in sediment‐hosted geothermal systems. These data provide the first evidence of submarine gas escape on the Central Kerguelen Plateau and expand our understanding of seafloor processes and carbon cycling in the data‐poor southern Indian Ocean. Extensive sedimentation of the Kerguelen Plateau and additional zones of submarine volcanic activity mean additional seeps or vents may lie outside the small survey area proximal to the islands.
Publisher: American Geophysical Union (AGU)
Date: 13-01-2004
DOI: 10.1029/2004EO020001
Publisher: American Geophysical Union (AGU)
Date: 21-10-2003
DOI: 10.1029/2003EO420003
Publisher: Elsevier BV
Date: 10-2004
Publisher: Wiley
Date: 23-08-2007
Publisher: American Geophysical Union (AGU)
Date: 10-2005
DOI: 10.1029/2004GC000867
Publisher: American Geophysical Union (AGU)
Date: 09-2003
DOI: 10.1029/2003GC000523
Publisher: American Geophysical Union (AGU)
Date: 12-1992
DOI: 10.1029/91TC02909
Publisher: Geological Society of America
Date: 2001
Publisher: Springer Science and Business Media LLC
Date: 10-1993
Publisher: American Geophysical Union (AGU)
Date: 04-2008
DOI: 10.1029/2007GC001780
Publisher: Public Library of Science (PLoS)
Date: 05-05-2016
Publisher: Oxford University Press (OUP)
Date: 08-1986
Publisher: Springer Science and Business Media LLC
Date: 27-04-2016
DOI: 10.1038/NCOMMS11375
Abstract: Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations ( P × 10 −8 ) with oestrogen receptor (ER)-negative breast cancer and BRCA1 -associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5 , a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations ( P .05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 05-02-1982
DOI: 10.1126/SCIENCE.215.4533.663
Abstract: The presence of newly discovered diapirs of presumed salt origin is documented for the continental margin of northeastern Kenya and southeastern Somalia. These structures are probably a manifestation of a significant thickness of Lower Jurassic evaporites deposited during the rift and early-drift stages of the separation of Madagascar from the African continent.
Publisher: Elsevier BV
Date: 15-04-2007
Publisher: Copernicus GmbH
Date: 22-10-2018
Abstract: Abstract. An International Ocean Discovery Program (IODP) workshop was held at Sydney University, Australia, from 13 to 16 June 2017 and was attended by 97 scientists from 12 countries. The aim of the workshop was to investigate future drilling opportunities in the eastern Indian Ocean, southwestern Pacific Ocean, and the Indian and Pacific sectors of the Southern Ocean. The overlying regional sedimentary strata are underexplored relative to their Northern Hemisphere counterparts, and thus the role of the Southern Hemisphere in past global environmental change is poorly constrained. A total of 23 proposal ideas were discussed, with ∼ 12 of these deemed mature enough for active proposal development or awaiting scheduled site survey cruises. Of the remaining 11 proposals, key regions were identified where fundamental hypotheses are testable by drilling, but either site surveys are required or hypotheses need further development. Refinements are anticipated based upon regional IODP drilling in 2017/2018, analysis of recently collected site survey data, and the development of site survey proposals. We hope and expect that this workshop will lead to a new phase of scientific ocean drilling in the Australasian region in the early 2020s.
Publisher: Geological Society of America
Date: 1993
Publisher: Geological Society of London
Date: 1992
Publisher: American Geophysical Union (AGU)
Date: 20-11-2007
DOI: 10.1029/2007EO470009
Publisher: Elsevier BV
Date: 02-1990
Publisher: Geological Society of America
Date: 05-1990
Publisher: Elsevier BV
Date: 02-2000
Publisher: American Geophysical Union
Date: 2000
DOI: 10.1029/GM121P0309
Publisher: American Geophysical Union (AGU)
Date: 09-2003
DOI: 10.1029/2003GC000535
Publisher: Geological Society of America
Date: 1995
Publisher: Geological Society of America
Date: 2015
Publisher: American Geophysical Union (AGU)
Date: 09-2005
DOI: 10.1029/2005GC000914
Publisher: American Geophysical Union (AGU)
Date: 12-04-2005
DOI: 10.1029/2005EO150002
Publisher: American Geophysical Union (AGU)
Date: 24-07-2012
DOI: 10.1029/2012EO300002
Publisher: Elsevier BV
Date: 08-2018
Publisher: Informa UK Limited
Date: 03-10-2017
Publisher: Springer Science and Business Media LLC
Date: 06-1996
DOI: 10.1007/BF00286086
Publisher: American Geophysical Union (AGU)
Date: 02-1994
DOI: 10.1029/93RG02508
Publisher: Geological Society of America
Date: 2008
DOI: 10.1130/G25059A.1
Publisher: Elsevier BV
Date: 10-2004
Publisher: Elsevier BV
Date: 07-2011
Publisher: Informa UK Limited
Date: 18-05-2016
Publisher: Springer Science and Business Media LLC
Date: 11-1986
DOI: 10.1038/324134A0
Publisher: American Association for the Advancement of Science (AAAS)
Date: 10-02-1995
DOI: 10.1126/SCIENCE.267.5199.852
Abstract: Widespread basalts and rhyolites were erupted in Madagascar during the Late Cretaceous. These are considered to be related to the Marion hot spot and the breakup of Madagascar and Greater India. Seventeen argon-40/argon-39 age determinations reveal that volcanic rocks and dikes from the 1500-kilometer-long rifted eastern margin of Madagascar were emplaced rapidly (mean age = 87.6 +/- 0.6 million years ago) and that the entire duration of Cretaceous volcanism on the island was no more than 6 million years. The evidence suggests that the thick lava pile at Volcan de l'Androy in the south of the island marks the focal point of the Marion hot spot at approximately 88 million years ago and that this mantle plume was instrumental in causing continental breakup.
Location: United States of America
Start Date: 07-2020
End Date: 12-2023
Amount: $626,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2016
End Date: 12-2020
Amount: $10,000,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 10-2005
End Date: 10-2006
Amount: $220,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2014
End Date: 12-2016
Amount: $3,600,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 01-2004
End Date: 06-2004
Amount: $30,000.00
Funder: Australian Research Council
View Funded Activity