Publication
Haemoglobin Epsilon as a Biomarker for the Molecular Detection of Canine Lymphoma
Publisher:
Baghdad University College of Veterinary Medicine
Date:
28-06-2023
DOI:
10.30539/IJVM.V47I1.1494
Abstract: Lymphoma is a cancer arising from B or T lymphocytes that are central immune system components. It is one of the three most common cancers encountered in the canine lymphoma affects middle-aged to older dogs and usually stems from lymphatic tissues, such as lymph nodes, lymphoid tissue, or spleen. Despite the advance in the management of canine lymphoma, a better understanding of the subtype and tumor aggressiveness is still crucial for improved clinical diagnosis to differentiate malignancy from hyperplastic conditions and to improve decision-making around treating and what treatment type to use. This study aimed to evaluate a potential novel biomarker related to iron metabolism, embryonic haemoglobin (HBE), for early diagnosis. Archived s les in combination with prospective s les collected from dogs with and without lymphoma were used in this study for the retrospective analyses of this tumor based on the same biomarker lified by real-time quantitative polymerase chain reaction. The HBE mRNA was aberrantly expressed in canine B and T cell lymphoma compared to the normal lymph node tissue and hyperplastic lymph nodes. In conclusion, this study identified a novel potential biomarker for improving lymphoma diagnosis and treatment in dogs. Further studies with larger s le sizes are needed to confirm the suitability of this biomarker for canine lymphoma diagnosis.