Discovery Projects - Grant ID: DP0773140

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0773140

Funding Status
Closed

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Funded Activity Summary

Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.

Funded Activity Details

Start Date: 01-2007

End Date: 05-2012

Funding Scheme: Discovery Projects

Funding Amount: $615,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological And Medical Chemistry | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Blood disorders | Cardiovascular system and diseases | Higher education |

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