Discovery Projects - Grant ID: DP0450338

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0450338

Funding Status
Closed

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Funded Activity Summary

Intracellular localisation of insulin signalling proteins in human skeletal muscle following exercise. The metabolic action of insulin in skeletal muscle is enhanced by exercise, but the underlying mechanisms mediating this are unknown. Insulin receptor substrate proteins are key mediators in the intracellular insulin signalling pathway and play a central role in regulating many metabolic events. Our aim is to examine the hypothesis that exercise induces a novel subcellular redistribution of these insulin receptor substrate proteins in skeletal muscle, such that the metabolic action of insulin is enhanced. Elucidating the mechanisms whereby exercise enhances insulin action underpins the development of new treatments and therapies with the aim of improving skeletal muscle function in health and disease.

Funded Activity Details

Start Date: 03-2004

End Date: 02-2007

Funding Scheme: Discovery Projects

Funding Amount: $165,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Exercise Physiology

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

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