Discovery Projects - Grant ID: DP140101509

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140101509

Funding Status
Closed

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Funded Activity Summary

Co-translational protein complex formation: a fundamental pathway of cellular organization? Multi-protein complexes constitute the most relevant molecular units of cellular function. Intriguingly, it remains enigmatic how eukaryotic cells assemble, with precision, hundreds of complexes in the crowded cytoplasmic compartment that produces thousands of nascent proteins at the same time. Recent work demonstrated that assembly of protein complexes can be initiated on nascent peptides as they emerge from the ribosome. This project proposes that these co-translational interactions constitute check-points of quality control mechanisms to ensure that only completely and properly assembled complexes are formed. This research is expected to uncover novel layers of cellular regulation that are of prime importance for the healthy state of all cells.

Funded Activity Details

Start Date: 06-2014

End Date: 12-2017

Funding Scheme: Discovery Projects

Funding Amount: $345,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | Biochemistry and Cell Biology | Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

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