Australian Laureate Fellowships - Grant ID: FL200100220

Funding Activity

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Funded Activity Summary

Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.

Funded Activity Details

Start Date: 02-2021

End Date: 01-2026

Funding Scheme: Australian Laureate Fellowships

Funding Amount: $3,364,492.00

Funder: Australian Research Council