Discovery Projects - Grant ID: DP0208773

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0208773

Funding Status
Closed

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Funded Activity Summary

The Molecular Basis of Copper Metabolism in Sheep. The unusual copper metabolism of sheep represents a significant agricultural problem. They are very susceptible to copper deficiency, but readily accumulate copper to toxic levels in the liver leading to fatal liver failure. We propose to elucidate the reason for the copper accumulation phenotype of sheep. We are focussing on WND, a copper transporter responsible for copper excretion into bile. We discovered a novel form of sheep WND designated WNDb to distinguish it from the normal form, WNDa. The experiments outlined are designed to understand the function of both proteins in the sheep and their role in copper sequestration.

Funded Activity Details

Start Date: 05-2002

End Date: 12-2004

Funding Scheme: Discovery Projects

Funding Amount: $180,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Biochemistry and Cell Biology | Cell Metabolism | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Sheep—meat | Sheep—wool | Inherited diseases (incl. gene therapy) |

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