Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP0453052
Funding Status
Closed
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Funded Activity Summary
In-line SPE-CE for the direct determination of drugs and metabolites in biological fluids based on porous polymer monoliths. A new approach is proposed for the development of novel micro- and nano-scale solid-phase adsorbent materials. These materials are based on porous polymer monoliths formed in situ within a capillary acting as a mould. The allows the material to be readily placed in a defined position, in a process similar to photo-patterning, and alleviates many of the problems usually associated with fabrication and miniaturisation. A simple photo-grafting process, initiated by UV light can be used for the selective chemical modification of these materials. These tailored monoliths can then be used for the in-line coupling of biological sample handling and capillary electrophoresis (CE) for the determination of drugs and related metabolites in biological fluids, thus avoiding time-consuming and costly off-line sample pre-treatment. This will lead to the development of new methods for the rapid determination of drugs, metabolites and other small molecules in clinical samples.Funded Activity Details
Start Date: 2004
End Date: 12-2009
Funding Scheme: Discovery Projects
Funding Amount: $320,000.00
Funder: Australian Research Council
Research Topics
ANZSRC Field of Research (FoR)
Diagnostic Applications | Analytical Chemistry | Separation Science | Macromolecular Chemistry Not Elsewhere Classified |
