Discovery Projects - Grant ID: DP140100002

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/API/grants/DP140100002

Funding Status
Closed

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Funded Activity Summary

Peptide-based Star Polymers for Improved Biointeraction and Targeted Anticancer Therapies. The aim of this project is to develop peptide-based star polymer nanocarriers for targeted drug delivery to cancer stem cells which integrate aptamer targeting technology and biointeraction studies with blood plasma fluid. The significance of this research is it pioneers the development of a drug delivery system that minimises plasma opsonization through understanding polymer-plasma interactions, which in turn increases tumour specificity and cell internalisation through incorporation of targeting aptamers and triggered drug release. This project will use rational design, advanced macromolecular engineering and an interdisciplinary collaboration to generate next-generation polymer therapeutics for drug delivery.

Funded Activity Details

Start Date: 2014

End Date: 12-2017

Funding Scheme: Discovery Projects

Funding Amount: $580,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Molecular Engineering of Nucleic Acids and Proteins | Macromolecular and Materials Chemistry | Biochemistry and Cell Biology not elsewhere classified | Nanochemistry and Supramolecular Chemistry

ANZSRC Socio-Economic Objective (SEO)

Cancer and Related Disorders |

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